Publications by authors named "B C Tel"
Article Synopsis
- Extracellular aggregation of amyloid-beta (Aβ) in the brain is linked to Alzheimer's disease (AD), and its intraneuronal accumulation may also contribute to disease progression.
- The study investigates the effect of tripeptidyl peptidase-1 (TPP1), a lysosomal enzyme, and its recombinant form (cerliponase alfa) in reducing Aβ levels within neuron cells while examining the role of autophagy.
- Results showed that cerliponase alfa decreased Aβ accumulation and triggered autophagy-related pathways, suggesting TPP1 enhancement might be a potential Alzheimer’s therapy.
Objective: Epigenetic mechanisms, including DNA methylation (DNAm), have been proposed to play a key role in Crohn's disease (CD) pathogenesis. However, the specific cell types and pathways affected as well as their potential impact on disease phenotype and outcome remain unknown. We set out to investigate the role of intestinal epithelial DNAm in CD pathogenesis.
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- - Stratified and precision nutrition focuses on tailoring dietary interventions to an individual's unique traits and environment to manage or prevent inflammatory bowel disease (IBD).
- - A literature review revealed four key themes in the context of IBD: nutrition's role in predicting IBD risk, food-based interventions, exclusive enteral nutrition (EEN) for Crohn's disease, and the use of pre- and probiotics in management.
- - There is a lack of sufficient evidence to provide specific dietary recommendations for IBD, necessitating further research to confirm initial findings and establish effective interventions.
Article Synopsis
- * There are currently no targeted treatments for either RAP or early CP, making it important to explore the underlying cell interactions that lead to disease progression.
- * This study found that inhibiting Orai1, a key signaling mechanism linked to calcium overload in pancreatic cells, can halt the progression of RAP and early CP, suggesting that targeting Orai1 might help prevent severe stages of CP.
Background And Aims: Thiopurine-induced acute pancreatitis (TIP) is one of the most common adverse events among inflammatory bowel disease patients treated with azathioprine (AZA), representing a significant clinical burden. Previous studies focused on immune-mediated processes, however, the exact pathomechanism of TIP is essentially unclear.
Methods: To model TIP in vivo, we triggered cerulein-induced experimental pancreatitis in mice receiving a daily oral dose of 1.