Aggregation induced emission luminogen bacteria hybrid bionic robot for multimodal phototheranostics and immunotherapy.

Multimodal phototheranostics utilizing single molecules offer a "one-and-done" approach, presenting a convenient and effective strategy for cancer therapy. However, therapies based on conventional photosensitizers often suffer from limitations such as a single photosensitizing mechanism, restricted tumor penetration and retention, and the requirement for multiple irradiations, which significantly constrain their application. In this report, we present an aggregation-induced emission luminogen (AIEgen) bacteria hybrid bionic robot to address above issues.

Empowering PARP inhibition through rational combination: Mechanisms of PARP inhibitors and combinations with a focus on the treatment of metastatic castration-resistant prostate cancer.

Poly (ADP-ribose) polymerase (PARP) inhibitors have revolutionized the treatment of many cancers. Metastatic castration-resistant prostate cancer (mCRPC) is an area where PARP inhibitors are intensively studied; the efficacy with PARP inhibitor monotherapy in patients with homologous recombination repair mutations following novel hormonal therapy have prompted the investigation of combination therapy, with adding an androgen receptor pathway inhibitor (ARPI) being one focus of research. Data on PARP inhibitor monotherapy and combination therapy for mCRPC are accumulating, and it is important to navigate through the complex data to inform treatment decision.

Facile Access to Piezoelectric Polyamides by Polyamidation of Carboxylic Acids and Ynamides for Potent Tumor Immunotherapy.

Polyamides are a fascinating group of piezoelectric materials that are largely synthesized by the polycondesation of dicarboxylic acids with diamines or the ring-opening polymerization of special lactams. However, developing a green polymerization approach for the facile synthesis of piezoelectric polyamides is highly desirable but also challenging. Here, a simple polyamidation of carboxylic acids and ynamides is successfully established to synthesize versatile piezoelectric polyamides.

Role of DNMT3a Expression and Nuclear Translocation under ELAVL1 mediation for Dendritic Cell Function and Th17/Treg Balance in COPD.

Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. The DNA methyltransferase DNMT3a has been implicated in COPD, however its upstream regulation and downstream mechanisms remain unclear.

Methods: Relative mRNA and protein levels of indicated genes in lung tissues and dendritic cells (DCs) were tested via qRT-PCR and western blot, respectively.

An Au-Se bond-based fluorescent nanoprobe for thermophoretic aggregation imaging of exosomal miRNAs.

Exosomal microRNAs (miRNAs) have recently gained prominence as promising biomarkers for non-invasive lung cancer screening. In this study, we innovatively developed an innovative fluorescent nanoprobe based on stable Au-Se bonds to detect lung cancer-associated miRNAs in exosomes. This nanoprobe integrates gold nanoparticles with selenated DNA molecular beacons (MBs) conjugated via 1,4-phenyldiisothiocyanate (PDITC).