Publications by authors named "B C T van Bussel"
Background And Objectives: Mortality prediction models are promising tools for guiding clinical decision-making and resource allocation in intensive care units (ICUs). Clearly specified predictor and outcome variables are necessary to enable external validation and safe clinical application of prediction models. The objective of this study was to identify the predictor and outcome variables used in different mortality prediction models in the ICU and investigate their reporting.
View Article and Find Full Text PDFThe outcome of kidneys transplanted following organ donation after euthanasia (ODE) remains unclear. This study analyzed all kidney transplantations in the Netherlands from January 2012 to December 2021, comparing the outcomes following ODE, donation after circulatory death (DCD-III), and donation after brain death (DBD). 9,208 kidney transplantations were performed: 148 ODE, 2118 DCD-III, and 1845 DBD.
View Article and Find Full Text PDFMost published prediction models for Coronavirus Disease 2019 (COVID-19) were poorly reported, at high risk of bias, and heterogeneous in model performance. To tackle methodological challenges faced in previous prediction studies, we investigated whether model updating and extending improves mortality prediction, using the Intensive Care Unit (ICU) as a proxy. All COVID-19 patients admitted to seven ICUs in the Euregio-Meuse Rhine during the first pandemic wave were included.
View Article and Find Full Text PDFComparison of the Quantra QPlus and ROTEM Goal-Directed Transfusion Protocols in Cardiothoracic Surgery Patients: A Prospective Observational Study.
J Cardiothorac Vasc Anesth
November 2024
Article Synopsis
- The study aimed to compare the transfusion recommendations of two treatment protocols: Quantra QPlus and ROTEM, specifically in patients undergoing elective cardiopulmonary bypass surgery.
- Researchers analyzed 100 samples from patients post-surgery, finding that the transfusion advice from the two protocols showed poor agreement overall and for specific transfusion needs like fibrinogen.
- The results indicate that the Quantra QPlus protocol may recommend unnecessary transfusions in non-bleeding patients, while it occasionally suggests transfusions when ROTEM does not, highlighting the need for adjustments in the Quantra QPlus protocol.
Monitoring of myocardial injury by serial measurements of QRS area and T area: The MaastrICCht cohort.
Ann Noninvasive Electrocardiol
September 2024
Background: Manually derived electrocardiographic (ECG) parameters were not associated with mortality in mechanically ventilated COVID-19 patients in earlier studies, while increased high-sensitivity cardiac troponin-T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were. To provide evidence for vectorcardiography (VCG) measures as potential cardiac monitoring tool, we investigated VCG trajectories during critical illness.
Methods: All mechanically ventilated COVID-19 patients were included in the Maastricht Intensive Care Covid Cohort between March 2020 and October 2021.