Immunogenicity and vaccine efficacy of -derived extracellular vesicles as a novel vaccine candidate.

(APP) is a significant pathogen in the swine industry, leading to substantial economic losses and highlighting the need for effective vaccines. This study evaluates the potential of APP-derived extracellular vesicles (APP-EVs) as a vaccine candidate compared to the commercial Coglapix vaccine. APP-EVs, isolated using tangential flow filtration (TFF) and cushioned ultracentrifugation, exhibited an average size of 105 nm and a zeta potential of -17.

Housing Relocation and Residential Satisfaction After Relocation: Effects of Dwelling Condition Changes on Older Adults in the Community.

Background: This study seeks to analyze the trajectories of residential satisfaction among older adults before and after relocation and explore the variability in the relationship between relocation and residential satisfaction based on changes in housing conditions during the relocation process.

Methods: Utilizing a nationally representative longitudinal dataset of older adults (N = 2718), this study employs individual-level fixed effect regression models to estimate the association between the timing of relocation and residential satisfaction. Stratified analyses are also conducted to explore how this association varies based on changes in housing conditions.

Effectiveness and Safety of Polydioxanone Thread Embedding Acupuncture Compared with Acupuncture Treatment for Knee Osteoarthritis: a Protocol for a Pilot, Assessor-Blinded, Randomized Controlled Trial.

Importance: Knee osteoarthritis (OA) is a common degenerative joint disease in aging populations. Knee OA is difficult to cure and requires ongoing management. Thread embedding acupuncture (TEA) is a popular Korean medical treatment for knee OA.

Mechanical-Stimuli-Driven Pseudo-Conductive Channels Along Dielectric Heterojunction Interfaces for Mechanoelectric Energy Conversion and Transmission.

Mechanoelectric energy conversion holds promise for energy conversion and transmission devices, yet conventional configurations rely on large-area conductive materials in active regions, limiting architectural design for cutting-edge devices. Here, a rational strategy is reported to create mechanical stimuli-driven pseudo-conductive (MSPC) channels entirely from dielectric materials, eliminating the need for electrodes in active regions. An in-depth investigation of MSPC channel formation mechanism at dielectric interfaces is conducted, employing energy band analyses.