Publications by authors named "B C STRAIGHT"
Article Synopsis
- * A new imaging agent, AKRO-6qcICG, can be applied to the surface of these tumors and helps surgeons see where cancer cells remain during surgery using near-infrared fluorescence.
- * In studies with patients, AKRO-6qcICG showed excellent sensitivity (100%) in detecting remaining cancer cells, indicating it could be a valuable tool to improve surgical outcomes and minimize additional treatments.
Purpose: Cysteine cathepsins are proteases that play a role in normal cellular physiology and neoplastic transformation. Elevated expression and enzymatic activity of cathepsins in breast cancer (BCa) indicates their potential as a target for tumor imaging. In particular cathepsin B (CTSB), L (CTSL), and S (CTSS) are used as targets for near-infrared (NIR) fluorescence imaging (FI), a technique that allows real-time intraoperative tumor visualization and resection margin assessment.
View Article and Find Full Text PDFThe goal of this study is to examine the association between in utero drought exposure and epigenetic age acceleration (EAA) in a global climate change hot spot. Calculations of EAA in adults using DNA methylation have been found to accurately predict chronic disease and longevity. However, fewer studies have examined EAA in children, and drought exposure in utero has not been investigated.
View Article and Find Full Text PDFSpine fusion surgery is one of the most common orthopedic procedures, with over 400,000 performed annually to correct deformities and pain. However, complications occur in approximately one third of cases. While many of these complications may be related to poor bone quality, it is difficult to detect bone abnormalities prior to surgery.
View Article and Find Full Text PDFObjectives: This study aimed to characterize mineral nutrition (copper, magnesium, selenium, and zinc) in Samburu pastoralist youth, in the context of differential cultural transitions due to uneven changes in educational access, herding intensity, polygyny, and access to wild, domesticated, and market-sourced foods.
Materials And Methods: Whole dried blood spots were collected in a total of 161 youth (highlands, = 97; lowlands, = 64) to assess concentrations of: cadmium, copper, lead, magnesium, mercury, selenium, and zinc. Concentrations were determined through Inductively Coupled Mass Spectrometry.