Evaluation of the Drug-Drug Interaction Potential of Cannabidiol Against UGT2B7-Mediated Morphine Metabolism Using Physiologically Based Pharmacokinetic Modeling.

Morphine is a commonly prescribed opioid analgesic used to treat chronic pain. Morphine undergoes glucuronidation by UDP-glucuronosyltransferase (UGT) 2B7 to form morphine-3-glucuronide and morphine-6-glucuronide. Morphine is the gold standard for chronic pain management and has a narrow therapeutic index.

Importance of pesticide and additional food in pest-predator system: a theoretical study.

Integrated pest management (IPM) combines chemical and biological control to maintain pest populations below economic thresholds. The impact of providing additional food for predators on pest-predator dynamics, along- side pesticide use, in the IPM context remains unstudied. To address this issue, in this work a theoretical model was developed using differential equations, assuming Holling type II functional response for the predator, with additional food sources included.

RNA-dependent RNA polymerase of predominant human norovirus forms liquid-liquid phase condensates as viral replication factories.

Many viral proteins form biomolecular condensates via liquid-liquid phase separation (LLPS) to support viral replication and evade host antiviral responses, and thus, they are potential targets for designing antivirals. In the case of nonenveloped positive-sense RNA viruses, forming such condensates for viral replication is unclear and less understood. Human noroviruses (HuNoVs) are positive-sense RNA viruses that cause epidemic and sporadic gastroenteritis worldwide.

Perception of Social Support and Prevalence of Self-Reported Depressive Symptoms among Patients with Head-and-Neck Squamous Cell Carcinoma Treated at a Tertiary Cancer Centre in North India.

Objectives: This study was conducted to determine and correlate the perception of social support and the prevalence of self-reported depressive symptoms among patients with head-and-neck squamous cell carcinoma (HNSCC).

Materials And Methods: This cross-sectional study included 100 patients with HNSCC receiving treatment at a tertiary cancer centre in north India. They were enrolled by a convenient sampling technique.

A transcriptomic comparison of in vitro models of the human placenta.

Introduction: Selecting an in vitro culture model of the human placenta is challenging due to representation of different trophoblast cell types with distinct biological roles and limited comparative studies that define key characteristics of these models. The aim of this research was to compare the transcriptomes of common in vitro models of the human placenta compared to bulk human placental tissue.

Methods: We performed differential gene expression analysis on publicly available transcriptomic data from 7 in vitro models of the human placenta (HTR-8/SVneo, BeWo, JEG-3, JAR, Primary Trophoblasts, Villous Explants, and Trophoblast Stem Cells) and compared to bulk placental tissue from 2 cohort studies (CANDLE and GAPPS) or individual trophoblast cell types derived from bulk placental tissue.