Publications by authors named "B C M Koh"
KX-01 (tirbanibulin, Klisyri®) is a recently FDA-approved drug for treating actinic keratosis, with a distinct dual mechanism of action combining microtubule disruption and non-ATP-competitive Src inhibition. This unique mechanism and novel chemotype highlight KX-01's potential as a payload for antibody-drug conjugates. In this study, we synthesized and evaluated KX-01 derivatives to enhance anticancer potency and explore functional groups suitable for antibody conjugation.
View Article and Find Full Text PDFThe best medical care for female football athletes should be evidence-based, and patient- and context-specific. A 2019 scoping review identified key knowledge gaps relating to the health of female footballers. Since then, research in women's football has been intensifying.
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- - The bone marrow microenvironment is crucial for regulating haematopoietic stem cell functions, and this study investigates whether different bone areas have unique properties and resilience, especially in the context of aging and inflammation.
- - Researchers found that the skull's bone marrow grows and becomes more vascularized throughout life, contributing significantly to blood cell production and showing resistance to typical aging effects like inflammation and fat accumulation.
- - The study highlights that changes in the skull’s bone marrow occur rapidly due to various conditions, including pregnancy and diseases like stroke, indicating that the skull offers a unique and adaptable environment compared to the more commonly studied femur.
Background & Aims: The epidemiology of adult primary liver cancer continues to evolve, owing to the increasing prevalence of metabolic disease, rising alcohol consumption, advances in vaccination for HBV, and antiviral therapy for HCV. Disparities in care and the burden of liver cancer between populations persist. We assess trends in the burden of liver cancer and contributions by various etiologies across 204 countries and territories from 2010 to 2021.
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