Computational Modeling and Experimental Investigation of CO-Hydrocarbon System Within Cross-Scale Porous Media.

CO flooding plays a crucial role in enhancing oil recovery and achieving carbon reduction targets, particularly in unconventional reservoirs with complex pore structures. The phase behavior of CO and hydrocarbons at different scales significantly affects oil recovery efficiency, yet its underlying mechanisms remain insufficiently understood. This study improves existing thermodynamic models by introducing Helmholtz free energy as a convergence criterion and incorporating adsorption effects in micro- and nano-scale pores.

Single-cell analysis of neoplastic plasma cells identifies myeloma pathobiology mediators and potential targets.

Multiple myeloma is a clonal plasma cell (PC) dyscrasia that arises from precursors and has been studied utilizing approaches focused on CD138 cells. By combining single-cell RNA sequencing (scRNA-seq) with scB-cell receptor sequencing (scBCR-seq), we differentiate monoclonal/neoplastic from polyclonal/normal PCs and find more dysregulated genes, especially in precursor patients, than we would have by analyzing bulk PCs. To determine whether this approach can identify oncogenes that contribute to disease pathobiology, mitotic arrest deficient-2 like-1 (MAD2L1) and S-adenosylmethionine synthase isoform type-2 (MAT2A) are validated as targets with drug-like molecules that suppress myeloma growth in preclinical models.

WFDC3 sensitizes colorectal cancer to chemotherapy by regulating ATM/ATR kinase signaling pathway.

Chemoresistance is an ongoing challenge for colorectal cancer (CRC) that significantly compromises the anti-tumor efficacy of current drugs. Identifying effective targets or drugs for overcoming chemoresistance is urgently needed. Our previous study showed that WFDC3 served as a tumor suppressor that hindered CRC metastasis.

Study on Aqueous Film Forming Foam Extinguishing Agents Based on Perfluorobranched Short-Chain Fluorocarbon-Hydrocarbon Surfactant Complex Mixtures.

Aqueous film-forming foam (AFFF) is a targeted product for liquid fuel fires and has the benefits of a long storage period and high fire extinguishing efficiency. However, because of the toxicity and bioaccumulation of the core raw material's long-chain fluorocarbon surfactant, traditional AFFF is being phased out. For this reason, three efficient AFFFs (F-1, F-2, and F-3; more details in Table 2) were designed using anionic surfactants (PBAF) with branched C perfluorinated chains, hexadecyltrimethylammonium bromide (CTAB), and dodecyl dimethyl betaine (BS-12) as core materials.

Ion bridging enables high-voltage polyether electrolytes for quasi-solid-state batteries.

Polyether electrolytes have been widely recognized for their favorable compatibility with lithium-metal, yet they are hampered by intrinsically low oxidation thresholds, limiting their potential for realizing high-energy Li-metal batteries. Here, we report a general approach involving the bridge joints between non-lithium metal ions and ethereal oxygen, which significantly enhances the oxidation stability of various polyether electrolyte systems. To demonstrate the feasibility of the ion-bridging strategy, a Zn ion-bridged polyether electrolyte (Zn-IBPE) with an extending electrochemical stability window of over 5 V is prepared, which enables good cyclability in 4.