Publications by authors named "B C H van der Wal"
Background: Addressing prosthetic joint infections poses a significant challenge within orthopedic surgery, marked by elevated morbidity and mortality rates. The presence of biofilms and infections attributed to () further complicates the scenario.
Objective: To investigate the potential of radioimmunotherapy as an innovative intervention to tackle biofilm-associated infections.
Article Synopsis
- Bacterial infections and antimicrobial resistance are major challenges for global healthcare, revealing limitations in traditional diagnostic and treatment methods and emphasizing the need for new approaches.
- Aptamers are synthetic oligonucleotides that show promise in managing bacterial infections by providing high specificity and effectiveness in both diagnosis and therapy, including early detection and suppressing bacterial growth.
- The review highlights how aptamers can also improve immune responses and serve in advanced treatment methods while discussing potential challenges like stability and degradation, aiming to expand their clinical applications.
Association of osteotomy, age, and component fixation with the outcomes of total hip arthroplasty in patients with hip dysplasia: a Dutch population-based registry study.
Acta Orthop
September 2024
Article Synopsis
- Hip dysplasia poses challenges for total hip arthroplasty (THA) due to anatomical differences, prompting a study to evaluate factors affecting implant survival and patient outcomes.
- Analyzing data from 7,465 patients treated from 2007 to 2021, the study categorized THAs based on age, prior pelvic osteotomy, and fixation methods, using statistical models to assess 5- and 10-year revision-free survival rates and reasons for revisions.
- The study found high 10-year revision-free survival (94.9%), but noted that younger patients and those with prior pelvic osteotomies had lower survival rates and reported worse patient-reported outcome measures (PROMs) compared to others.
Article Synopsis
- The ACE-X implant is a special 3D-printed device made of titanium to help dogs with a hip problem called hip dysplasia.
- In a study with 34 dogs, the implant showed good results like better hip coverage and less pain over time, even after a year.
- Although some dogs had minor complications, the majority (over 90%) felt better, proving the ACE-X implant is a helpful option for treating this condition in dogs.
Introduction: Implant infections caused by Staphylococcus aureus are responsible for high mortality and morbidity worldwide. Treatment of these infections can be difficult especially when bacterial biofilms are involved. In this study we investigate the potential of infrared photoimmunotherapy to eradicate staphylococcal infection in a mouse model.
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