Publications by authors named "B C G Sabbe"
Background: Although there is clear evidence that therapeutic drug monitoring (TDM) has beneficial effects for patients treated with tricyclic antidepressants, it is generally not recommended for second-generation antidepressants (SGA). However, it has been suggested that methodological shortcomings might influence the results in TDM studies with SGA.
Aim: A qualitative assessment of randomized controlled trials (RCTs) that specifically investigated drug concentration-effect relationships of SGA in patients with major depressive disorder (MDD) to analyze the potential benefit of TDM during treatment with these agents.
Article Synopsis
- There is evidence suggesting that the HPA axis may not function properly in people with chronic tinnitus, but previous studies have shown mixed results, possibly due to varied clinical factors.
- This study compares salivary cortisol levels in tinnitus sufferers and healthy controls to investigate the effects of childhood trauma and anxiety on HPA-axis functioning.
- The results indicate that individuals with tinnitus who experienced childhood trauma have lower cortisol awakening responses, suggesting trauma impacts HPA function, while anxiety did not significantly affect any outcomes.
Article Synopsis
- Depression is typically viewed as a disease caused by a common factor, but this study takes a network approach, focusing on how individual symptoms influence each other and their dynamics over time.
- Using the Symptom Questionnaire-48 (SQ-48), researchers examined patient data with dynamic time warp analyses, discovering significant interconnections between various symptoms and how certain symptoms led to changes in others.
- The study identified five symptoms ('hopeless', 'restless', 'down/depressed', 'feeling tense', and 'no enjoyment') that could be targeted for more effective, personalized treatments, though the focus on severely depressed inpatients limits the generalizability of the findings.
Background: Psychiatry may currently hold unprecedented knowledge in the diagnosis and treatment of psychiatric conditions. Yet, there is a widely held belief that this knowledge is not adequately integrated, nor does it fully account for the complexity of the phenomena under study.
Objective: To assess the effectiveness of a system-oriented and network-focused approach in capturing and integrating the complexity of psychiatric disorders.
Background: While theta burst stimulation (TBS) shows promise in Major Depressive Disorder (MDD), its effectiveness in bipolar depression (BD-D) remains uncertain. Optimizing treatment parameters is crucial in the pursuit of rapid symptom relief. Moreover, aligning with personalized treatment strategies and increased interest in immunopsychiatry, biomarker-based stratification of patients most likely to benefit from TBS might improve remission rates.
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