Publications by authors named "B C ADLER"
Evidence for targeting autonomic dysfunction in systemic sclerosis: A scoping review.
J Scleroderma Relat Disord
January 2025
Autonomic dysfunction is a common and early complication among patients with systemic sclerosis, suggesting that it may play a role in the pathogenesis of the disease and be a potential target for therapeutic interventions. Although the true prevalence of autonomic dysfunction among patients with systemic sclerosis is still unclear, it is estimated that as many as 80% of patients may be affected. Autonomic dysfunction may lead to widespread multi-organ dysfunction through its effects on the cardiovascular system, gastrointestinal tract, urinary tract, sweat and salivary glands, and pupils.
View Article and Find Full Text PDFThe American Contact Dermatitis Society (ACDS) selected sulfites as the 2024 Allergen of the Year. These common and potentially allergenic ingredients are used as preservatives and antioxidants in a variety of foods, beverages, medications, and personal care products. In this article, we review common sources of sulfite exposure, clinical manifestations of allergic contact dermatitis (ACD) to sulfites, and patch testing considerations for this emerging allergen.
View Article and Find Full Text PDFArticle Synopsis
- - Eyelid dermatitis is a prevalent skin condition characterized by inflammation, with allergic contact dermatitis (ACD) being the most common cause, triggered by exposure to allergens.
- - Common allergens linked to eyelid dermatitis include metals, fragrances, preservatives, and certain medications found in cosmetics and everyday products.
- - Effective treatment focuses on avoiding allergens and includes patient education on recognizing triggers; the review also covers signs, evaluation methods, and patch testing for diagnosis.
Article Synopsis
- This study explored the role of cytochrome-P450 eicosanoids, specifically 20-HETE and EETs, in regulating blood pressure and vascular stiffness among 1,054 young adults.
- Researchers found that higher plasma levels of 20-HETE were positively associated with increased systolic blood pressure and vascular stiffness measurements, even after accounting for other factors like sex and body mass index.
- The study concluded that 20-HETE significantly influences blood pressure and vascular health in young adults, while EETs did not show a significant impact in these areas.
Article Synopsis
- Asgard archaea, key ancestors of Eukaryotes, have mobile genetic elements (MGEs) that are not well understood, and this study investigates two complete genomes from the Atabeyarchaeia lineage to explore these elements.
- The research identifies 18 MGEs in Atabeyarchaeia, including a notable 20.67 kbp circular plasmid and specific viruses that might influence their evolution through gene interactions.
- Differences in defense mechanisms, such as restriction-modification systems, between Atabeyarchaeia and another Asgard archaea, Freyarchaeia, highlight how these systems can affect the relationship with MGEs and contribute to genetic diversity in these organisms.*