Publications by authors named "B Button"
Article Synopsis
- Hyper IgE syndrome (STAT3-HIES), also known as Job's syndrome, results from mutations in the STAT3 gene, leading to chronic respiratory infections due to compromised pulmonary defense mechanisms.
- The study aimed to investigate how these STAT3 mutations affect the airway epithelium's ability to defend against infections, analyzing sputum properties and lung tissue from patients.
- Findings revealed that STAT3 deficiency disrupts critical airway functions, including mucus secretion and ciliary movement, contributing to increased infection risk and inflammation in patients with this syndrome.*
Introduction: The Northern Ontario School of Medicine University seeks to address rural physician shortages in Northern Ontario. One key strategy the school employs is the use of experiential learning placements embedded throughout its undergraduate curriculum. In second year, students embark on two 4-week placements in rural and remote communities.
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- - Rural communities face worse health outcomes than urban areas, mainly due to limited access to healthcare, highlighting the importance of medical education in those settings to increase rural physician supply.
- - Pre-clerkship medical students participated in mandatory rural placements, where they gained insights into rural generalism primarily through interactions with rural physician faculty, emphasizing the role of effective precepting in their learning experience.
- - The findings suggest that sociocultural learning theory explains how students learn during these placements, while place-based education theory can enhance the curriculum; thus, training preceptors effectively is crucial for positive student experiences.
Repetitive bouts of coughing expose the large airways to significant cycles of shear stress. This leads to the release of alarmins and the tussive agent adenosine triphosphate (ATP) which may be modulated by the activity of ion channels present in the human airway. This study aimed to investigate the role of the transient receptor potential subfamily vanilloid member 2 (TRPV2) channel in mechanically induced ATP release from primary bronchial epithelial cells (PBECs).
View Article and Find Full Text PDFObjective: Physical activity and exercise are key components in the management of cystic fibrosis (CF). Completing exercise programs online may minimize the risk of cross-infection and increase access for people with CF. This study aimed to understand the perspectives of people with CF regarding intervention content for a telehealth exercise program.
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