Publications by authors named "B Burroni"
Introduction: Small-cell lung carcinoma (SCLC) is a high-grade neuroendocrine carcinoma of poor prognosis. Although immune checkpoint blockers have shown promising results in advanced SCLC, the tumor immune microenvironment (TME) remains poorly understood, with no validated prognostic or predictive biomarkers of efficacy.
Methods: This retrospective study included surgically samples from 48 SCLC patients between 2009 and 2018.
Article Synopsis
- Primary testicular lymphoma (PTL) is a rare form of diffuse large B-cell lymphoma (DLBCL), making up 1%-2% of DLBCL cases and is linked to poor outcomes due to high rates of central nervous system relapse.
- In a study of 15 patients (5 with PTL and 10 with DLBCL involving the testes), treatment with high-dose methotrexate and R-CHOP showed a 73% complete response (CR) rate overall, with 100% CR in PTL patients and only 55% in DLBCL-T patients.
- The molecular similarities between PTL and primary CNS lymphoma (PCNSL) indicate they may have common origins, highlighting
Article Synopsis
- * Researchers excluded pregnancies that ended in termination or miscarriage and those with prior blood cancer histories, focusing on the survival rates and maternal health during these malignancies compared to healthy pregnancies.
- * The study found that of nearly 10 million pregnancies analyzed, 1,366 were associated with haematological cancers, providing new insights into their incidence and effects on maternal morbidity and mortality.
Article Synopsis
- - Obinutuzumab (O) and rituximab (R) were compared in a long-term study (LyMa-101) for treating newly diagnosed mantle cell lymphoma (MCL) patients, focusing on outcomes like measurable residual disease (MRD), progression-free survival (PFS), and overall survival (OS).
- - Results showed that the O group had a higher rate of MRD negativity (83.1% vs 63.4%) and better long-term outcomes, with 5-year PFS at 82.8% and OS at 86.4%, compared to 66.6% and 71.4% for the R group, respectively.
- - The study concluded that using
Article Synopsis
- A 33-year-old man had headaches and vision problems, and doctors found a mass in his brain that was linked to HCL.
- After treatment with special medicines, he got better quickly and is doing well a year later; other similar cases show that the same treatments can work for more patients with HCL in the brain.