Publications by authors named "B Bueno-de-Mesquita"
Pleiotropic variants (i.e., genetic polymorphisms influencing more than one phenotype) are often associated with cancer risk.
View Article and Find Full Text PDFGenome-wide association studies (GWAS) are a powerful tool for detecting variants associated with complex traits and can help risk stratification and prevention strategies against pancreatic ductal adenocarcinoma (PDAC). However, the strict significance threshold commonly used makes it likely that many true risk loci are missed. Functional annotation of GWAS polymorphisms is a proven strategy to identify additional risk loci.
View Article and Find Full Text PDFDioxins and polychlorinated biphenyls (PCBs) are toxic, endocrine disruptors and persistent chemicals for which the main exposure source is diet due to their bioaccumulation and biomagnification in food chains. Cohort studies in the general populations have reported inconsistent associations between these chemicals in serum/plasma and mortality. Our objective was to study the association between dietary intake of 17 dioxins and 35 PCBs and all-cause, cancer-specific and cardiovascular-specific mortalities were assessed in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
View Article and Find Full Text PDFArticle Synopsis
- Modern non-Africans have 1-3% Neandertal DNA due to interbreeding events that occurred 50,000-60,000 years ago, which may affect traits linked to diseases like pancreatic ductal adenocarcinoma (PDAC).
- In this study, researchers examined how specific Neandertal-related genetic variations (aSNPs) correlate with PDAC risk in European and East Asian populations, using data from over 200,000 individuals.
- While no significant link was found in Europeans, a specific allele in East Asians was associated with a 35% increased risk of developing PDAC, suggesting only a limited role of Neandertal genes in this cancer's risk.
Article Synopsis
- - The study examined the relationship between amino acid levels and colorectal cancer risk using data from the EPIC and UK Biobank cohorts, focusing on 654 colorectal cancer cases and matched controls in EPIC.
- - Results indicated that higher levels of histidine were linked to a reduced risk of colorectal cancer, with similar findings for glutamine, although the association for glutamine was not as strong.
- - The findings suggest that elevated histidine levels may lower the risk of colorectal cancer, highlighting the need for further research into amino acid metabolism's role in cancer development.