Publications by authors named "B Bucheton"
Article Synopsis
- The study investigates the presence of African trypanosomes in the skin of individuals at risk for gambiense Human African Trypanosomiasis (gHAT) in Guinea, finding that a significant number of seropositive individuals carry the parasites in their dermal layers.
- Out of nearly 19,000 screened participants, 96 were included, revealing dermatological symptoms to be more common in seropositive individuals compared to seronegative ones.
- Follow-up showed a decrease in skin parasite detection post-treatment, but a notable percentage of untreated seropositive individuals continued to test positive, highlighting potential challenges in achieving gHAT elimination.
Background: Serological screening tests play a crucial role to diagnose gambiense human African trypanosomiasis (gHAT). Presently, they preselect individuals for microscopic confirmation, but in future "screen and treat" strategies they will identify individuals for treatment. Variability in reported specificities, the development of new rapid diagnostic tests (RDT) and the hypothesis that malaria infection may decrease RDT specificity led us to evaluate the specificity of 5 gHAT screening tests.
View Article and Find Full Text PDFStrategies to detect Human African Trypanosomiasis (HAT) cases rely on serological screening of populations exposed to trypanosomes. In Guinea, mass medical screening surveys performed with the Card Agglutination Test for Trypanosomiasis have been progressively replaced by door-to-door approaches using Rapid Diagnostic Tests (RDTs) since 2016. However, RDTs availability represents a major concern and medical teams must often adapt, even in the absence of prior RDT performance evaluation.
View Article and Find Full Text PDFArticle Synopsis
- Trypanosoma brucei infects subcutaneous white adipose tissue, potentially aiding in its own transmission and contributing to weight loss in infected individuals.
- The study reveals that T. brucei infection increases IL-17A-producing immune cells in adipose tissue, and a lack of IL-17 signaling protects against weight loss and fat wasting from the infection.
- Additionally, without IL-17 signaling, preadipocytes accumulate and more parasites are found outside blood vessels in the adipose tissue, emphasizing the importance of IL-17 in managing immune responses and tissue dynamics during T. brucei infection.