Publications by authors named "B Bruzzone"
Article Synopsis
- Next-generation sequencing (NGS) is replacing Sanger sequencing for HIV genotypic drug resistance testing, and this study assessed how consistent different interpretation tools are in a real-world setting.
- The research involved analyzing NGS results from 11 Italian labs using the AD4SEQ HIV-1 Solution v2 kit and compared interpretations from SmartVir, HyDRA Web, and Stanford HIVdb.
- Findings indicated that viremia levels and HIV subtypes influence the validity of NGS-GRT, with only mutations present at frequencies over 10% showing reliable agreement among the interpretation tools.
: The steady spread of dengue virus (DENV) poses a profound public health threat worldwide. Reverse transcription real-time polymerase chain reaction (RT2-PCR) has been increasingly recognized as a reference method for the diagnosis of acute dengue infection. The goal of this study was to assess the diagnostic accuracy of five different RT2-PCR kits for the detection of DENV in a historically processed set of sera samples.
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- The study examines T-cell characteristics in individuals with perinatal HIV (PHIV), adults with HIV (AHIV), and healthy controls, focusing on activation, exhaustion, and regulatory T-cell frequencies.
- It involved a cross-sectional analysis of young people with controlled HIV and healthy individuals, using various immunological markers to identify differences between groups.
- Results showed PHIV had a healthier T-cell profile with lower exhaustion markers and higher naive T-cell frequencies than AHIV, suggesting that the timing of HIV infection influences immune system status.
Influenza-like illness (ILI) patients co-detected with respiratory pathogens exhibit poorer health outcomes than those with single infections. To address the paucity of knowledge concerning the incidence of concurrent respiratory pathogens, their relationships, and the clinical differences between patients detected with single and multiple pathogens, we performed an in-depth characterization of the oropharyngeal samples of primary care patients collected in Genoa (Northwest Italy), during winter seasons 2018/19-2019/20.The apriori algorithm was employed to evaluate the incidence of viral, bacterial, and viral-bacterial pairs during the study period.
View Article and Find Full Text PDFNew therapies and vaccines changed the management of COVID-19. The aim of this retrospective study was to describe characteristics, in-hospital mortality and its predictors in patients with moderate/severe COVID-19, considering the 4 different pandemic waves and viral variants' prevalence from February 2020 to January 2022. Among 1135 patients included, 873 (77%) had at least one comorbidity, 177 (16%) were immunocompromised.
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