Publications by authors named "B Brodacki"
Article Synopsis
- The study investigates the role of brain-derived neurotrophic factor (BDNF) and specific genetic variations (SNPs) in the early-onset of Parkinson's disease (PD), focusing on patients under 55 years old.
- Researchers analyzed the genetic profiles of 163 PD patients and 91 healthy controls, revealing that individuals with the AG genotype of the BDNF gene have a threefold higher risk of developing early PD compared to those with the GG genotype.
- The findings also showed that lower levels of serum BDNF were associated with the AG and AA genotypes, indicating that the Val66Met polymorphism in the BDNF gene contributes to lower blood BDNF levels and increased risk of early-onset
Purpose: The natural clinical course of cerebral small vessel disease (CSVD) was not thoroughly described. The aim of this single center cohort study was to establish biochemical predictors of vascular events and death in CSVD patients during a 24-month follow-up.
Patients And Methods: A total of 130 functionally independent patients with marked MRI features of CSVD and recent lacunar stroke (n = 52,LS), vascular Parkinsonism (n = 28,VaP) or dementia (n = 50,VaD) were prospectively recruited.
Diseases related to DNA polymerase gamma dysfunction comprise of heterogeneous clinical presentations with variable severity and age of onset. Molecular screening for the common POLG variants: p.Ala467Thr, p.
View Article and Find Full Text PDFObjectives: Endothelial dysfunction has been implicated in the pathogenesis of cerebral small-vessel disease (SVD). Little is known about the relationship between SVD and measures of endothelium-dependent vasodilatation and cerebral vasomotor reactivity. The aim of this study was to evaluate cerebral and extracerebral endothelial dysfunction in patients with different manifestations of SVD and to assess the relationship between endothelial dysfunction and radiologic markers of SVD.
View Article and Find Full Text PDFBackground: Endothelial dysfunction (ED) is involved in the pathogenesis of cerebral small vessel disease (SVD), however, it is not clear if specific biomarkers related to ED are associated with radiological progression of SVD.
Methods: A single-center, prospective cohort study was conducted among consecutive, adult patients with SVD. Logistic regression was used to analyze the association of each baseline biomarker (highest vs lowest tertile) and the MRI radiological outcome after 2 years.