Publications by authors named "B Brent"
Article Synopsis
- * Despite its benefits, institutional policies like human participation protection training (HPP) create obstacles for community partnerships, making it difficult for organizations to engage effectively in studies.
- * The ongoing study "Fostering Opportunities in Research through Messaging and Education" (FOR ME) highlights these challenges and proposes a guide to streamline HPP training for community partners, aiming to enhance their participation in research initiatives.
Repeated coronavirus infections in childhood drive progressive maturation of systemic immune responses into adulthood. Analyses of immune responses in children have focused primarily upon systemic assessment but the importance of mucosal immunity is increasingly recognised. We studied virus-specific antibody responses in contemporaneous nasal swabs and blood samples from 99 children (4-15 years) and 28 adults (22-56 years), all of whom had prior SARS-CoV-2 infection.
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- Omicron variants of SARS-CoV-2 are the most prevalent worldwide, causing high infection rates in children aged 6-14 years, whose immune responses were examined post-infection.
- Initial Omicron infections in children lead to a weak antibody response; however, reinfections or vaccinations significantly boost antibody production and improve neutralization against various Omicron subvariants.
- Prior exposure to SARS-CoV-2 (pre-Omicron) enhances antibody responses after Omicron infections, although these antibodies mainly target the original virus strain, while strong cellular immune responses provide protection against severe disease across different variants.
Antibody Persistence After Primary SARS-CoV-2 Infection and Protection Against Future Variants Including Omicron in Adolescents: National, Prospective Cohort Study.
Pediatr Infect Dis J
June 2023
Background: Antibodies are a measure of immunity after primary infection, which may help protect against further SARS-CoV-2 infections. They may also provide some cross-protection against SARS-CoV-2 variants. There are limited data on antibody persistence and, especially, cross-reactivity against different SARS-CoV-2 variants after primary infection in children.
View Article and Find Full Text PDFParents' and teachers' attitudes to and experiences of the implementation of COVID-19 preventive measures in primary and secondary schools following reopening of schools in autumn 2020: a descriptive cross-sectional survey.
BMJ Open
September 2022
Objective: To assess implementation and ease of implementation of control measures in schools as reported by staff and parents.
Design: A descriptive cross-sectional survey.
Setting: Staff and parents/guardians of the 132 primary schools and 19 secondary schools participating in COVID-19 surveillance in school kids (sKIDs and sKIDsPLUS Studies).