Publications by authors named "B Breant"
Article Synopsis
- Serotonergic psychedelics like psilocin can significantly alter consciousness, with growing evidence suggesting they might improve long-term mental health and help treat disorders such as depression.
- Research using mice showed that psilocin delays REM sleep onset and reduces NREM sleep maintenance for about 3 hours after administration, affecting brain wave patterns but not long-term sleep quantity.
- While psilocin didn't change the overall recovery dynamics from sleep deprivation, it did slow down the recovery of sleep's slow-wave activity, indicating its effects on both vigilance and sleep regulation could be important for its potential antidepressant benefits.
Key Points: Inputs impinging on layer 5 pyramidal neurons perform essential operations as these cells represent one of the most important output carriers of the cerebral cortex. However, the contribution of astrocytes, a type of glial cell, to these operations is poorly documented. Here we found that optogenetic activation of astrocytes in the vicinity of layer 5 in the mouse primary visual cortex induces spiking in local pyramidal neurons through Nav1.
View Article and Find Full Text PDFObjective: High glucocorticoid levels in rodents inhibit development of beta cells during fetal life and lead to insulin deficiency in adulthood. To test whether similar phenomena occur in humans, we compared beta-cell function in adults who were exposed to glucocorticoids during the first part of fetal life with that of nonexposed subjects.
Research Design And Methods: The study was conducted in 16 adult participants exposed to glucocorticoids during the first part of fetal life and in 16 nonexposed healthy participants with normal glucose tolerance who were matched for age, sex, and body mass index (BMI).
Background And Aims: c-Myc is highly expressed in pancreatic multipotent progenitor cells (MPC) and in pancreatic cancer. The transition from MPC to unipotent acinar progenitors is associated with c-Myc downregulation; a role for c-Myc in this process, and its possible relationship to a role in cancer, has not been established.
Design: Using coimmunoprecipitation assays, we demonstrate that c-Myc and Ptf1a interact.