Publications by authors named "B Brauer"
Article Synopsis
- BFL1, an antiapoptotic protein from the BCL2 family, is linked to hematological cancers but hasn't been extensively researched.
- Two articles present the development of selective BFL1 inhibitors, starting from hit identification using a covalent fragment library and leading to optimized compounds.
- One compound not only induced cell death in specific cancer cell lines but also stabilized the BFL1 protein, significantly increasing its half-life to 10.8 hours while activating cellular apoptosis markers.
Article Synopsis
- Glycosylation is crucial for modifying lipids and sorting proteins, with its regulation involving a unique distribution of enzymes in the Golgi and the action of SPPL3.
- In cells lacking the retention factor LYSET/TMEM251, there is increased secretion of a Golgi protein, B4GALT5, due to disrupted M6P tagging, which typically marks proteins for lysosomal degradation.
- The study reveals that GOLPH3 and GOLPH3L adaptors play a critical role in stabilizing the LYSET-GNPT complex, maintaining proper Golgi function, and ensuring efficient lysosomal enzyme processing.
Autism spectrum disorders (ASD) are complex neurodevelopmental conditions characterized by impairments in social communication, repetitive behaviors, and restricted interests. Epigenetic modifications serve as critical regulators of gene expression playing a crucial role in controlling brain function and behavior. Lysine (K)-specific demethylase 6B (KDM6B), a stress-inducible H3K27me3 demethylase, has emerged as one of the highest ASD risk genes, but the precise effects of KDM6B mutations on neuronal activity and behavioral function remain elusive.
View Article and Find Full Text PDFBackground: The VPS50 protein functions in synaptic and dense core vesicle acidification, and perturbations of VPS50 function produce behavioral changes in Caenorhabditis elegans. Patients with mutations in VPS50 show severe developmental delay and intellectual disability, characteristics that have been associated with autism spectrum disorders (ASDs). The mechanisms that link VPS50 mutations to ASD are unknown.
View Article and Find Full Text PDFLTR-retrotransposons are transposable elements characterized by the presence of long terminal repeats (LTRs) directly flanking an internal coding region. They share genome organization and replication strategies with retroviruses. Steamer-like Element-1 (SLE-1) is an LTR-retrotransposon identified in the genome of the Chilean blue mussel .
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