Publications by authors named "B Bourgeois"
FOXOs are highly dynamic transcription factors consisting of one conserved DNA-binding domain (forkhead domain) as well as intrinsically disordered regions (IDRs) at the N- and C-termini. These IDRs are essential and regulate transcriptional activity of FOXOs by serving as interaction platform for cofactors. Furthermore, the IDRs are involved in intra- and intermolecular homeotypic and heterotypic interactions between FOXOs and in turn mediate FOXO auto-inhibition and condensate formation.
View Article and Find Full Text PDFThe insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1) is a conserved RNA-binding protein that regulates RNA stability, localization and translation. IGF2BP1 is part of various ribonucleoprotein (RNP) condensates. However, the mechanism that regulates its assembly into condensates remains unknown.
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- * A study showed that rabbits lacking B vitamins experienced significant vascular damage when given Hcy, despite low cholesterol levels, including issues like collagen disorganization and impaired vascular reactivity.
- * Findings indicate that Hcy promotes atherogenic changes in the aorta, suggesting its harmful effects extend beyond just high cholesterol conditions.
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- Alcohol misuse in people with HIV and chronic binge alcohol in SIV-infected macaques lead to increased physical frailty and impaired muscle function, with specific microRNAs (myomiRs) involved in this impairment.
- Previous research found that myomiRs are expressed differently in muscle from alcohol-administered macaques, impacting the differentiation of muscle stem cells (myoblasts).
- The current study showed that delivering extracellular vesicle (EV)-carried miR-206 improves myoblast differentiation and muscle cell growth, suggesting EVs could be a potential treatment to enhance muscle function in individuals affected by alcohol-related issues.
Metabolic enzymes can adapt during energy stress, but the consequences of these adaptations remain understudied. Here, we discovered that hexokinase 1 (HK1), a key glycolytic enzyme, forms rings around mitochondria during energy stress. These HK1-rings constrict mitochondria at contact sites with the endoplasmic reticulum (ER) and mitochondrial dynamics protein (MiD51).
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