Publications by authors named "B Bouffandeau"
Article Synopsis
- The study investigated the occurrence of dynamic left intraventricular obstruction (IVO) in septic shock patients and its relationship with volume status, fluid responsiveness, and mortality rates.
- Out of 218 septic shock patients, 22% exhibited IVO, with a significantly higher 28-day mortality rate in those affected (55% vs. 33%).
- Findings revealed that patients with IVO had hypercontractile left ventricles and demonstrated marked improvements in stroke index and reduced IVO after fluid infusions, indicating a strong link between IVO and fluid responsiveness.
Aim: Because "metformin-associated lactic acidosis" refers to metformin and concurrent pathologies as co-precipitating factors, the respective impact in the outcome of metformin therapy, metformin accumulation, and general diseases should be determined. We therefore constructed a model of sepsis in mice treated with metformin at a dose corresponding to clinical practice, or to accumulation.
Methods: 460 mice were separated in 3 groups: no metformin therapy, a 7-day metformin therapy at 50 mg.