inhibition of co-expressed DIPs and Dprs shapes neural development.

In , two interacting adhesion protein families, Dprs and DIPs, coordinate the assembly of neural networks. While intercellular DIP/Dpr interactions have been well characterized, DIPs and Dprs are often co-expressed within the same cells, raising the question as to whether they also interact in . We show, in cultured cells and that DIP-α and DIP-δ can interact in with their ligands, Dpr6/10 and Dpr12, respectively.

The mechanosensitive ion channel ASIC2 mediates both proprioceptive sensing and spinal alignment.

By translating mechanical forces into molecular signals, proprioceptive neurons provide the CNS with information on muscle length and tension, which is necessary to control posture and movement. However, the identities of the molecular players that mediate proprioceptive sensing are largely unknown. Here, we confirm the expression of the mechanosensitive ion channel ASIC2 in proprioceptive sensory neurons.

Molecular characterization of the intact mouse muscle spindle using a multi-omics approach.

The proprioceptive system is essential for the control of coordinated movement, posture, and skeletal integrity. The sense of proprioception is produced in the brain using peripheral sensory input from receptors such as the muscle spindle, which detects changes in the length of skeletal muscles. Despite its importance, the molecular composition of the muscle spindle is largely unknown.

Waiving goodbye to youth: Jurors perceive transferred juveniles differently from adults but render similar verdicts.

Juveniles are developmentally different from adults but are often treated similarly in the criminal justice system. In case processing, many juveniles are transferred to adult courts. Before case processing, many juveniles are interrogated with the same tactics used against adults.