Publications by authors named "B Bona"

Article Synopsis
  • Nucleic acids can effectively silence disease-related genes and have advantages over small molecule drugs, such as high specificity and the ability to target hard-to-reach molecules.
  • However, their instability in biological settings and quick clearance from the body pose challenges, leading to the need for nanocarriers.
  • Spherical nucleic acids (SNA) made from highly fluorinated DNA amphiphiles offer improved stability in biological media and promise better delivery of nucleic acid therapies for gene silencing.
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The covalent functionalization of polymers with fluorinated moieties represents a promising strategy for the development of multimodal systems. Moreover, polymer fluorination often endows the resulting nanocarriers with improved colloidal stability in the biological environment. In this work, we developed fluorinated pegylated (PEG) biodegradable poly(ε-caprolactone) (PCL) drug nanocarriers showing both high colloidal stability and stealth properties, as well as being (F)-Nuclear Magnetic Resonance (NMR) detectable.

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This work presents a robotic application aimed at performing environmental monitoring in data centers. Due to the high energy density managed in data centers, environmental monitoring is crucial for controlling air temperature and humidity throughout the whole environment, in order to improve power efficiency, avoid hardware failures and maximize the life cycle of IT devices. State of the art solutions for data center monitoring are nowadays based on environmental sensor networks, which continuously collect temperature and humidity data.

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Dietary plant flavonoids have been proposed to contribute to cancer prevention, neuroprotection, and cardiovascular health through their anti-oxidant, anti-inflammatory, pro-apoptotic, and antiproliferative activities. As a consequence, flavonoid supplements are aggressively marketed by the nutraceutical industry for many purposes, including pediatric applications, despite inadequate understanding of their value and drawbacks. We show that two flavonoids, luteolin and quercetin, are promiscuous endocrine disruptors.

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