Positron Emission Tomography Based Elucidation of the Enhanced Permeability and Retention Effect in Dogs with Cancer Using Copper-64 Liposomes.

Since the first report of the enhanced permeability and retention (EPR) effect, the research in nanocarrier based antitumor drugs has been intense. The field has been devoted to treatment of cancer by exploiting EPR-based accumulation of nanocarriers in solid tumors, which for many years was considered to be a ubiquitous phenomenon. However, the understanding of differences in the EPR-effect between tumor types, heterogeneities within each patient group, and dependency on tumor development stage in humans is sparse.

FACTOR ANALYSES OF THE McGILL PAIN QUESTIONNAIRE (MPQ) IN ACUTE AND CHRONIC PAIN PATIENTS.

The McGill Pain Questionnaire (MPQ) aims to measure sensory, affective, and evaluative dimensions of pain. However, the structural dimensionality of the MPQ remains somewhat uncertain. Exploratory (EFA) factor analyses were used to investigate the structure of the MPQ based on the responses of a diverse sample of 448 pain patients (M age = 43.