Anomalies in Hadronic B Decays.

In this Letter, we perform fits to B→PP decays, where B={B^{0},B^{+},B_{s}^{0}} and the pseudoscalar P={π,K}, under the assumption of flavor SU(3) symmetry [SU(3)_{F}]. Although the fits to ΔS=0 or ΔS=1 decays individually are good, the combined fit is very poor: there is a 3.6σ disagreement with the SU(3)_{F} limit of the standard model (SM_{SU(3)_{F}}).

Wasp Venom: Future Breakthrough in Production of Antimicrobial Peptides.

The emergence of multi-drug-resistant pathogens and the decrease in the discovery of newer antibiotics have led to a quest for novel alternatives. Recently, wasp venom has spiked interest due to the presence of various active compounds, showcasing a diverse range of therapeutic effects. Wasps are creatures of the Hymenoptera order, and their venom chemically comprises antimicrobial peptides such as Anoplin, Mastoparan, Polybia-CP, Polydim-I, and Polybia MP1 that play a significant role in the biological effects of the venom.

Benchmarking DFT approximations for studying apatites.

Despite the growing interest in apatites, available experimental studies on their properties are limited in scope. Researchers, therefore, are increasingly resorting to predictions using density functional theory (DFT). However, large deviations can be seen between DFT-based estimates and experimental results, presumably due to approximations made in DFT models.

Dual inhibition of HERs and PD-1 counteract resistance in KRAS-mutant head and neck cancer.

Background: Basket clinical trials targeting the KRAS-mutation in solid tumors have shown initial promise, including in orphan KRAS head and neck cancer (HNC). However, development of resistance to KRAS-mutant-specific inhibitors (KRASi) remains a major obstacle. Here, we investigated the intrinsic (tumor-cell autonomus) and tumor-microenvironment (TME) mechanisms of resistance to the KRASi-MRTX849 and AMG510 in a unique syngenic murine KRAS-mutated HNC cell line.

Synergistic Catalytic Sites in High-Entropy Metal Hydroxide Organic Framework for Oxygen Evolution Reaction.

The integration of multiple elements in a high-entropy state is crucial in the design of high-performance, durable electrocatalysts. High-entropy metal hydroxide organic frameworks (HE-MHOFs) are synthesized under mild solvothermal conditions. This novel crystalline metal-organic framework (MOF) features a random, homogeneous distribution of cations within high-entropy hydroxide layers.