Publications by authors named "B Berenice Campa-Cordoba"
Alzheimer's disease (AD) is clinically characterized by a progressive loss of cognitive functions and short-term memory. AD patients present two distinctive neuropathological lesions: neuritic plaques and neurofibrillary tangles (NFTs), constituted of beta-amyloid peptide (Aβ) and phosphorylated and truncated tau proteins. Aβ deposits around cerebral blood vessels (cerebral amyloid angiopathy, CAA) is a major contributor to vascular dysfunction in AD.
View Article and Find Full Text PDFAlzheimer's disease (AD) is a neurodegenerative disease, characterized histopathologically by intra-neuronal tau-related lesions and by the accumulation of amyloid β-peptide (Aβ) in the brain parenchyma and around cerebral blood vessels. According to the vascular hypothesis of AD, an alteration in the neurovascular unit (NVU) could lead to Aβ vascular accumulation and promote neuronal dysfunction, accelerating neurodegeneration and dementia. To date, the effects of insoluble vascular Aβ deposits on the NVU and the blood-brain barrier (BBB) are unknown.
View Article and Find Full Text PDFThe current pandemic caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a public health emergency. To date, March 1, 2021, coronavirus disease 2019 (COVID-19) has caused about 114 million accumulated cases and 2.53 million deaths worldwide.
View Article and Find Full Text PDFAlzheimer's disease (AD) is the most common neurodegenerative disease worldwide. Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and aggregates of amyloid β peptide (Aβ) both in the brain parenchyma as neuritic plaques, and around blood vessels as cerebral amyloid angiopathy (CAA). According to the vascular hypothesis of AD, vascular risk factors can result in dysregulation of the neurovascular unit (NVU) and hypoxia.
View Article and Find Full Text PDFArticle Synopsis
- About 50 million people suffer from dementia globally, with Alzheimer's disease being the most prevalent type, leading to significant disability among the elderly.
- Alzheimer's is marked by memory loss and cognitive decline, with key brain lesions included neuritic plaques and neurofibrillary tangles caused by tau protein abnormalities.
- The review discusses how tau undergoes pathological changes—like hyperphosphorylation and truncation—contributing to the progression from pre-NFTs to NFTs, highlighting the role of the PHF core in forming these tangles and tau phosphorylation's potential protective effects.