Publications by authors named "B Bayramov"
Article Synopsis
- Chemotherapy effectively kills rapidly dividing cancer cells but struggles to eliminate slower-dividing cancer stem cells and dormant cells, leading to reduced effectiveness with prolonged treatment.
- A study was conducted using a specific cancer cell model to analyze how chemotherapy affects gene expression related to cancer cell survival and dormancy by comparing treated and untreated cells in mice.
- Findings revealed that chemotherapy alters the expression of genes associated with cancer cell dormancy and survival, while downregulating pathways that initiate cell death, suggesting new targets for improving treatment outcomes against drug resistance.
Article Synopsis
- The study investigates the link between the C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of colorectal polyps in the Azerbaijani population, aiming to enhance personalized medicine for CRC prevention.
- It compared 125 patients with colon polyps to 155 healthy controls, analyzing DNA through specific laboratory techniques.
- Results showed no significant associations between the gene variants and disease risk, indicating that factors like age, sex, smoking, and alcohol use did not differ significantly between the patient and control groups.
The principal aim of the current study was to investigate the relationship between T>C (rs2292832) and C>T (rs11614913) small non-coding RNA polymorphisms and the risk of developing CRC in the Azerbaijani population. The study included 120 patients diagnosed with CRC and 125 healthy individuals. Peripheral blood samples were collected from all the subjects in EDTA tubes and DNA extraction was performed by salting out.
View Article and Find Full Text PDFBackground & Objectives: Imatinib mesylate (IM) is a reliable first line treatment for chronic myeloid leukaemia (CML). Nevertheless, despite promising results, a considerable proportion of patients develop resistance to the drug. Cytochrome P450 (CYP) enzymes play a crucial role in IM metabolism.
View Article and Find Full Text PDFNecrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in preterm infants. Despite significant advances made in the prevention and treatment of disease so far, there has not been much change in the rate of mortality and morbidity associated with NEC. Although the factors affecting the development of necrotizing enterocolitis are not yet known precisely, prematurity is thought to be the most important risk factor for the development of NEC.
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