Meta-nudging and mental health: Using social influencers to change opinions and behaviors that positively impact mental health.

A central challenge in mental healthcare is effectively disseminating accurate, evidence-based information to encourage behaviors that improve well-being. Nudges, though widely used, often yield small, short-lived effects in changing behaviors. An alternative approach, meta-nudging, uses social influencers to indirectly change beliefs and behaviors by shifting norms within a social group.

A review of current and proposed behavioral nudge strategies to improve the readiness of the United States military.

This review discusses findings on the use of behavioral nudges in both the Canadian and U.S. military.

Recruitment of autophagy initiator TAX1BP1 advances aggrephagy from cargo collection to sequestration.

Autophagy mediates the degradation of harmful material within lysosomes. In aggrephagy, the pathway mediating the degradation of aggregated, ubiquitinated proteins, this cargo material is collected in larger condensates prior to its sequestration by autophagosomes. In this process, the autophagic cargo receptors SQSTM1/p62 and NBR1 drive cargo condensation, while TAX1BP1, which binds to NBR1, recruits the autophagy machinery to facilitate autophagosome biogenesis at the condensates.

Oxidative stress alters mitochondrial homeostasis in isolated brain capillaries.

Background: Neurovascular deficits and blood-brain barrier (BBB) dysfunction are major hallmarks of brain trauma and neurodegenerative diseases. Oxidative stress is a prominent contributor to neurovascular unit (NVU) dysfunction and can propagate BBB disruption. Oxidative damage results in an imbalance of mitochondrial homeostasis, which can further drive functional impairment of brain capillaries.