Publications by authors named "B Barberio"
Crohn's disease (CD) is a chronic, complex inflammatory disorder of the gastrointestinal tract that presents significant therapeutic challenges. Despite the availability of a wide range of treatments, many patients experience primary non-response, secondary loss of response, or adverse events, limiting the overall effectiveness of current therapies. Clinical trials often report response rates below 60%, partly due to stringent inclusion criteria.
View Article and Find Full Text PDFBackground: Freezing donor fecal microbiota has improved fecal microbiota transplantation (FMT) for recurrent C. difficile infection (CDI), achieving short-term effectiveness similar to fresh-samples. Research shows frozen fecal matter remains effective for up to 12-months at -80 °C.
View Article and Find Full Text PDFUpper gastrointestinal Crohn's disease: What are we talking about?
United European Gastroenterol J
December 2024
Article Synopsis
- Pouchitis is an inflammatory disease that can affect ileal pouches, potentially leading to pouch failure, and this study looks into the effects of a specific probiotic strain, DG®, on this condition.
- In a randomized trial with 52 patients post-restorative proctocolectomy, participants received either DG® or a placebo for 8 weeks, during which researchers monitored inflammatory cytokine levels in the pouch mucosa at multiple points.
- Results showed that the group receiving DG® had significantly reduced levels of inflammatory cytokines after 8 weeks compared to their baseline, indicating the probiotic may positively influence the pouch microenvironment.