Towards molecular structure discovery from cryo-ET density volumes via modelling auxiliary semantic prototypes.

Cryo-electron tomography (cryo-ET) is confronted with the intricate task of unveiling novel structures. General class discovery (GCD) seeks to identify new classes by learning a model that can pseudo-label unannotated (novel) instances solely using supervision from labeled (base) classes. While 2D GCD for image data has made strides, its 3D counterpart remains unexplored.

Visible-Light-Mediated Cascade 1,4-Hydrogen Atom Transfer versus Dearomative Spirocyclization of -Benzylacrylamides: Divergent Access to Functionalized γ-Ketoamides and 2-Azaspiro[4.5]decanes.

Visible-light-driven metal- and photocatalyst-free cascade 1,4-HAT and dearomative spirocyclization of -benzylacrylamides are described for sustainable synthesis of a variety of pharmaceutically important γ-ketoamides and 2-Azaspiro[4.5]decanes in one pot in good to excellent yields. Readily accessible and nontoxic materials, expensive Ir or Ru photocatalyst-free mild conditions, excellent functional group tolerance, operational simplicity, and scalability enhance the practical value of this protocol.

Ralstonia pickettii bacteremia: A retrospective review of records.

Introduction: Ralstonia pickettii is a non-fermenting gram-negative bacillus rarely associated with hospital-acquired infections. The study aimed to characterise the clinical profile and outcomes of R. pickettii bacteremia cases.

Antilipase and antioxidant activities of topiramate-phenolic acid conjugates: Computational modelling, synthesis, and in-vitro investigations.

A series of ten topiramate-phenolic acid conjugates (T1-T10) were synthesized, and evaluated for their pancreatic lipase inhibitory and antioxidant potentials. The design of the compounds reflected the structural attributes extracted from robust QSAR models developed for predicting the pancreatic lipase inhibition potency. Conjugate T4 competitively inhibited pancreatic lipase with IC value of 8.