Publications by authors named "B B Rosenblum"
Our main objective was to validate that hyperspectral imaging via a new portable camera carries the potential to provide a reliable clinical biomarker that can predict DFU healing. We recruited patients with diabetic foot ulceration (DFU) without peripheral arterial disease, infection or other serious illness. Using an hyperspectral imaging (HSI) apparatus, post-debridement hyperspectral images were taken evaluating the ulcer size, periwound oxyhemoglobin (OxyHb), deoxyhemoglobin level (DeoxyHb) and oxygen saturation (O Sat) for four consecutive visits.
View Article and Find Full Text PDFThe formation of a stable G-quadruplex (GQ) can inhibit the increased telomerase activity that is common in most cancers. The global structure and the thermal stability of the GQs are usually evaluated by spectroscopic methods and thermal denaturation properties. However, most biochemical processes involving GQs might require local conformational changes at the guanine tetrad (G4) level.
View Article and Find Full Text PDFThe chr12q24.13 locus encoding OAS1-OAS3 antiviral proteins has been associated with coronavirus disease 2019 (COVID-19) susceptibility. Here, we report genetic, functional and clinical insights into this locus in relation to COVID-19 severity.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers conducted tests using a mouse model with the EPAS1A529V mutation to examine vascular malformations through various imaging techniques and histological analyses.
- * Results indicated that patients and mutant mice exhibited a range of vascular malformations, with the patient vessels showing a higher presence of mutations compared to normal tissue, establishing vascular malformation as a new clinical characteristic of EPAS1 gain-of-function syndrome.
Background And Purpose: A new transtentorial venous system consisting of medial, intermediate, and lateral tentorial veins, connecting infra- and supratentorial compartments, was recently shown in 2 cadaver dissections and 2 patient scans. We sought to characterize the venous patterns within the tentorium and their relation to measures of skull development in a cohort of healthy adults.
Materials And Methods: We retrospectively reviewed tentorial venous anatomy of the head using CTA/CTV performed for routine care or research purposes in 238 patients.