A study on the relationship between physical exercise and feelings of inferiority among college students: the chain mediating effect of social support and emotional regulation ability.

Objective: This study aims to explore the impact of physical exercise on feelings of inferiority among college students, focusing on the mediating roles of social support and emotional regulation ability. The research investigates both direct and indirect pathways to understand how physical exercise enhances psychological resilience and mitigates negative self-perceptions.

Methods: A sample of 2,036 college students from 15 provinces in China was surveyed using validated scales for physical exercise, feelings of inferiority, social support, and emotional regulation ability.

Fundamentals of intervertebral disc degeneration and related discogenic pain.

Lumbar intervertebral disc degeneration is thought to be the main cause of low back pain, although the mechanisms by which it occurs and leads to pain remain unclear. In healthy adult discs, vessels and nerves are present only in the outer layer of the annulus fibrosus and in the bony endplate. Animal models, and histological and biomechanical studies have shown that annulus tear or endplate injury is the initiating factor for painful disc degeneration.

Role of neurogenic inflammation in intervertebral disc degeneration.

In healthy intervertebral discs (IVDs), nerves and blood vessels are present only in the outer annulus fibrosus, while in degenerative IVDs, a large amount of nerve and blood vessel tissue grows inward. Evidence supports that neurogenic inflammation produced by neuropeptides such as substance P and calcitonin gene related peptide released by the nociceptive nerve fibers innervating the IVDs plays a crucial role in the process of IVD degeneration. Recently, non-neuronal cells, including IVD cells and infiltrating immune cells, have emerged as important players in neurogenic inflammation.

Bolstered bone regeneration by multiscale customized magnesium scaffolds with hierarchical structures and tempered degradation.

Addressing irregular bone defects is a formidable clinical challenge, as traditional scaffolds frequently fail to meet the complex requirements of bone regeneration, resulting in suboptimal healing. This study introduces a novel 3D-printed magnesium scaffold with hierarchical structure (macro-, meso-, and nano-scales) and tempered degradation (microscale), intricately customized at multiple scales to bolster bone regeneration according to patient-specific needs. For the hierarchical structure, at the macroscale, it can feature anatomic geometries for seamless integration with the bone defect; The mesoscale pores are devised with optimized curvature and size, providing an adequate mechanical response as well as promoting cellular proliferation and vascularization, essential for natural bone mimicry; The nanoscale textured surface is enriched with a layered double hydroxide membrane, augmenting bioactivity and osteointegration.

An ammonia-responsive aerogel-type colorimetric sensor for non-destructive monitoring of shrimp freshness.

The colorimetric sensor for volatile amines (VA) detection can realize non-destructive monitoring of shrimp quality. However, its sensing performance still needs to be improved. In this study, we proposed an aerogel-type colorimetric sensor to improve VA sensing performance and realize early detection of shrimp spoilage.