Publications by authors named "B B Obeng"
Objective: Routine viral load and drug resistance testing are well supported in most resource-rich settings and provide valuable benefits in the clinical care of PLWH in these communities. Undoubtedly, there exist financial and political constraints for the scale-up of viral load and drug resistance testing in Sub-Saharan Africa. To achieve the global UNAIDS 95/95/95 targets, there is the need to bridge this inequity in patient care and allow for a universal approach that leaves no community behind.
View Article and Find Full Text PDFCetylpyridinium chloride (CPC) is a quaternary ammonium antimicrobial used in numerous personal care products, human food, cosmetic products, and cleaning solutions. Yet, there is minimal published data on CPC effects on eukaryotes, immune signaling, and human health. Previously, we showed that low-micromolar CPC inhibits rat mast cell function by inhibiting antigen (Ag)-stimulated Ca mobilization, microtubule polymerization, and degranulation.
View Article and Find Full Text PDFArticle Synopsis
- - The study compared Sanger sequencing and next-generation sequencing (NGS) to detect drug-resistance mutations in HIV-1 among treatment-naive patients in Ghana, aiming to find minority mutations that could lead to treatment failure.
- - NGS identified 25 mutations in the HIV genes compared to 21 by Sanger sequencing, revealing a higher detection rate of minority drug resistance mutations (55% vs. 35%).
- - Results suggest NGS is more effective for accurate drug resistance testing and highlight the need for its implementation in clinical settings in Ghana, as Sanger sequencing alone may miss significant mutations.
Article Synopsis
- - Exosomes are tiny extracellular vesicles that help cells communicate and play a complex role in central nervous system disorders, having both positive and negative effects.
- - Recent research highlights their involvement in neurodegenerative diseases, showing how they carry proteins and reflect the internal cellular environment.
- - The article focuses on the production and functions of exosomes as potential biomarkers in neurodegenerative disorders, emphasizing their protective roles in nervous tissue regeneration and healing.
People are exposed to high concentrations of antibacterial agent cetylpyridinium chloride (CPC) via food and personal care products, despite little published information regarding CPC effects on eukaryotes. Here, we show that low-micromolar CPC exposure, which does not cause cell death, inhibits mitochondrial ATP production in primary human keratinocytes, mouse NIH-3T3 fibroblasts, and rat RBL-2H3 immune mast cells. ATP inhibition via CPC (EC 1.
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