Von Hippel-Lindau syndrome with bilateral renal and an interaortocaval mass.

Patients with bilateral renal masses and an interaortocaval mass (IACM) present a complex scenario where, in addition to renal masses, management of the IACM adds to challenges in an already challenging case. A young man in his 30s presented with left flank pain, associated with loss of appetite, headache and sweating. The evaluation revealed multiple renal masses in the right kidney, a large mass in the left kidney and an IACM.

Analysis of anti-cancer and anti-inflammatory activity in Typhonium flagelliforme rhizome extract by induction of apoptosis: An in-vitro study.

Plants are major source of bioactive compounds. Typhonium flagelliforme is an important medicinal plant that has various health benefits and crucial properties including analgesic activity, antimicrobial activity, anti-inflammatory activity and anticancer activity. This study aims to determine the anticancer and anti-inflammatory potential in aqueous, acetone, ethanolic, and methanolic extracts of Typhonium flagelliforme against various cell lines using various molecular techniques.

Evidenced-Based Recommendation for Involving Mothers to Reduce the Procedural Pain and Stress in High-Risk Neonates: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Background: Neonates admitted to the neonatal intensive care unit (NICU) undergo several painful procedures, causing significant stress. Maternal involvement in neonatal care significantly reduces pain and stress, thereby supporting better neurodevelopment in neonates.

Clinical Question: How do maternal involvement strategies reduce neonatal pain and pain-related stress in the NICU?

Data Sources: A systematic search was conducted on CENTRAL, PubMed Medline, EMBASE, CINAHL, Scopus, Web of Science, ProQuest databases, and Google Scholar for studies published between January 2007 and March 2024.

Targeting and engineering biomarkers for prostate cancer therapy.

Prostate cancer (PCa) is the second most commonly occurring cancer among men worldwide. Although the clinical management of PCa has significantly improved, a number of limitations have been identified in both early diagnosis and therapeutic treatment. Because multiple studies show that prostate-specific antigen (PSA) screening frequently results in overdiagnosis and overtreatment, the use of PSA alone as a diagnostic marker for PCa screening has been controversial.

Enhanced rivastigmine delivery through nanoemulsion and pyridoxine supplementation: An in-vivo study on Alzheimer's disease intervention.

Nanoemulsions are nanostructured material and stabilized colloidal in nature evolved as a highly desirable mechanism for the delivery of drugs. Our objective of the study deals with a successful Rivastigmine (RSG) loaded nanoemulsion which can effectively progress the treatment of AD patients. We developed nanoemulsion containing RSG by combining pyridoxine, an essential vitamin supplement for central nervous system development, with linseed oil, which functioned as the lipophilic phase in the nanoemulsion formulation.