PARP1 promotes tumor proliferation in lenalidomide-resistant multiple myeloma via the downregulation of microRNA-192-5p-AKT signaling.

Background: Lenalidomide-based therapies are recommended as first-line treatment for multiple myeloma (MM) patients, regardless of the transplant eligibility. Resistance to lenalidomide is a clinical problem that urgently needs to be addressed. The expression of poly(ADP-ribose) polymerase 1 (PARP1) is abnormally high in a variety of tumor tissues including MM.

Nanostructured electroless Ni deposited SnO for solar hydrogen production.

Herein, Ni-decorated SnO (Ni@SnO) nanostructures have been synthesized using SnO as a matrix a simple electroless deposition method for the generation of hydrogen, a potent near-future fuel. XRD analysis confirmed the generation of rutile SnO in Ni@SnO. FESEM and FETEM imaging exhibited the formation of SnO nanoparticles with a size of 10-50 nm, which are deposited with Ni nanoparticles (5-7 nm) and intermittent films (thickness 1-2 nm).

Microstructure tuned NaV(PO)@C electrodes toward ultra-long-life sodium-ion batteries.

Sodium-ion batteries (SIBs) are emerging as the best replacement for Li-ion batteries. In this regard, research on developing a reliable cathode material for SIBs is burgeoning. Rhombohedral NaV(PO) (NVP), is a typical sodium super ionic conductor (NASICON) type material having prominent usage as a cathode material for SIBs.

Mapping the cancer surface proteome in search of target antigens for immunotherapy.

Immune-based therapeutic interventions recognizing proteins localized on the cell surface of cancer cells are emerging as a promising cancer treatment. Antibody-based therapies and engineered T cells are now approved by the Food and Drug Administration to treat some malignancies. These therapies utilize a few cell surface proteins highly expressed on cancer cells to release the negative regulation of immune activation that limits antitumor responses (e.

Solid state engineering of BiS/rGO nanostrips: an excellent electrode material for energy storage applications.

The study presents a novel, one-pot, and scalable solid-state reaction scheme to prepare bismuth sulphide (BiS)-reduced graphene oxide (rGO) nanocomposites using bismuth oxide (BiO), thiourea (TU), and graphene oxide (GO) as starting materials for energy storage applications. The impact of GO loading concentration on the electrochemical performance of the nanocomposites was investigated. The reaction follows a diffusion substitution pathway, gradually transforming BiO powder into BiS nanostrips, concurrently converting GO into rGO.