Durability of response of UGN-101: Longitudinal follow up of multicenter study.

Purpose: UGN-101, a reverse thermal mitomycin gel for upper tract instillation, recently became the first FDA approved treatment for upper tract urothelial carcinoma (UTUC). However, the durability of UGN-101 treatment has not been well described. Here we present long term outcomes from our multi-institutional cohort for patients who initially responded to treatment.

A phase II study of ramucirumab and somatostatin analog therapy in patients with advanced neuroendocrine tumors.

Objectives: Well-differentiated neuroendocrine tumors (NET) are highly vascular tumors characterized by their expression of vascular endothelial growth factor (VEGF). This trial investigated the activity of ramucirumab, a monoclonal antibody that targets VEGF receptor-2 (VEGFR-2) and inhibits activity of VEGF, in combination with somatostatin analog therapy in patients (pts) with advanced extra-pancreatic NET.

Methods: We conducted a single-arm phase II trial enrolling pts with advanced, progressive extra-pancreatic NET.

The Simons Observatory: Design, Optimization, and Performance of Low-Frequency Detectors.

The Simons Observatory (SO) is a cosmic microwave background (CMB) experiment located in the Atacama Desert in Chile that will make precise temperature and polarization measurements over six spectral bands ranging from 27 to 285 GHz. Three small aperture telescopes (SATs) and one large aperture telescope (LAT) will house 60,000 detectors and cover angular scales between one arcminute and tens of degrees. We present the performance of the dichroic, low-frequency (LF) lenslet-coupled sinuous antenna transition-edge sensor (TES) bolometer arrays with bands centered at 27 and 39 GHz.

Artificial Urinary Sphincter Placement Before or After Radiation Therapy: Does Timing of Radiation Impact Surgical Complications and Continence?

Objectives: To evaluate the impact of radiation timing on artificial urinary sphincter (AUS) outcomes. AUS is the gold standard treatment for post-prostatectomy incontinence. Radiation history has been associated with worse outcomes, including higher rates of erosion and infection.