Publications by authors named "B B Jensen"
Courses of SARS-CoV-2 infections are highly variable, ranging from asymptomatic to lethal COVID-19. Though research has shown that host genetic factors contribute to this variability, cohort-based joint analyses of variants from the entire allelic spectrum in individuals with confirmed SARS-CoV-2 infections are still lacking. Here, we present the results of whole genome sequencing in 1,220 mainly vaccine-naïve individuals with confirmed SARS-CoV-2 infection, including 827 hospitalized COVID-19 cases.
View Article and Find Full Text PDFThe evolutionary conservation of the building plan of the heart suggests this organ is under substantial form-function constraints. Its form varies to such a degree, however, that it questions whether we understand the form-function relations of the heart. A previously published image of the heart of the sunfish (Mola mola, Tetraodontiformes) indicates the presence of an exceptionally simple topology of the chambers.
View Article and Find Full Text PDFBackground And Objective: Treatment burden refers to the overall impact of medical treatments on a patient's well-being and daily life. Our objective is to evaluate the impact of treatment burden on quality of life (QoL) in patients with genitourinary (GU) malignancies, highlighting the importance of patient-reported outcomes (PROs) in clinical trials to inform treatment decisions and improve patient care.
Methods: We conducted a narrative review of clinical trials focused on GU malignancy (prostate, bladder, and kidney) between January 2000 and June 2024, analyzing related PROs and findings regarding treatment burden.
Primary carnitine deficiency may mimic hypertrophic cardiomyopathy and be mistakenly attributed to genotype-negative sarcomeric protein dysfunction in hypertrophic cardiomyopathy. Although rare, timely diagnosis may have significant implications on management and should prompt testing of family members.
View Article and Find Full Text PDFArticle Synopsis
- The study examined cognitive symptoms in individuals infected with SARS-CoV-2, finding that while most had mild respiratory symptoms, many also experienced cognitive issues like attention and memory deficits.
- At baseline, those with SARS-CoV-2 showed higher fatigue levels compared to those who tested negative, but improvements in cognitive scores were noted in both groups over time.
- Ultimately, the research highlights that even mild cases of COVID-19 can be linked to increased fatigue and cognitive challenges, reinforcing previous findings.