Publications by authors named "B B Ingold"

There is a high prevalence of vitamin D insufficiency and deficiency worldwide likely because of both limited sun-exposure and inadequate dietary intake. Meat, including pork, is not typically considered a dietary source of vitamin D, possibly because of management practices that raise pigs in confinement. This experiment determined the vitamin D content of loin and subcutaneous adipose tissue in sun-exposed finisher pigs.

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Traditional confinement practices limit exposure to sunlight and vitamin D synthesis, and vitamin insufficiency occurs even with dietary supplementation. The aim of this study was to determine the effect of limited sun exposure on serum concentration of vitamin D and the expression of vitamin D synthesizing enzymes in the liver and kidney of pigs on a vitamin D sufficient diet. White-pigmented grower pigs (29.

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Article Synopsis
  • The study investigates the mechanisms behind brain metastasis in renal cell cancer (RCC), linking chemokine expression to increased brain metastasis risk.
  • Evidence shows that 15% of RCC patients had brain metastases at autopsy, with high expression of CXCR4 and increased CCR2 and CCL7 in brain lesions compared to primary tumors.
  • Findings suggest that CCR2 mediates monocyte recruitment, playing a significant role in the development of brain metastases in RCC patients.
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Unlabelled: To determine whether metastasis to brain is associated with altered expression patterns of integrins, we investigated the expression of αvβ3, αvβ5, αvβ6 and αvβ8 integrins in primary malignancies and metastases to brain of breast, lung and renal carcinomas and in malignant melanoma. Inhibitors of αv integrins are currently in clinical trials for glioblastoma. The role of integrins in the process of brain metastasis from other human tumors is unknown.

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