Publications by authors named "B B Hanekamp"
Purpose: To investigate the influence of a micro-enema on diagnostic performance, submucosal width, reader confidence, and tumor conspicuity using MRI to stage early rectal cancers (ERC).
Methods: In this single-center study, we consecutively included 50 participants with assumed ERC who all completed MRI with (MRin) and without (MRex) a micro-enema. The diagnostic performance was recorded for two experienced radiologists using histopathology as the gold standard.
Article Synopsis
- Squamous cell carcinoma of the anus (SCCA) can come back after treatment, and identifying responses early is key for personalized care, but current data on imaging biomarkers is limited and often conflicting.
- The study analyzed data from four trials, looking at diffusion-weighted MRI scans to see if changes in the tumor's apparent diffusion coefficient (ADC) could predict treatment failure during chemoradiotherapy.
- Results showed that while a change in ADC could indicate different rates of locoregional failure, no ADC-based metrics significantly predicted treatment failure overall, highlighting the need for more comprehensive studies on radiological biomarkers in the future.
Background: In staging early rectal cancers (ERC), submucosal tumor depth is one of the most important features determining the possibility of local excision (LE). The micro-enema (Bisacodyl) induces submucosal edema and may hypothetically improve the visualization of tumor depth.
Purpose: To test the diagnostic performance of MRI to identify ERC suitable for LE when adding a pre-procedural micro-enema and concurrent use of a modified classification system.
Purpose: To analyze tumor characteristics derived from pelvic magnetic resonance imaging (MRI) of patients with squamous cell carcinoma of the anus (SCCA) before and during chemoradiotherapy (CRT), and to compare the changes in these characteristics between scans of responders vs. nonresponders to CRT.
Methods: We included 52 patients with a pelvic 3T MRI scan prior to CRT (baseline scan); 39 of these patients received an additional scan during week 2 of CRT (second scan).
Background: Accurate target volume delineation is a prerequisite for high-precision radiotherapy. However, manual delineation is resource-demanding and prone to interobserver variation. An automatic delineation approach could potentially save time and increase delineation consistency.
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