Publications by authors named "B Aracil"
Assessment of the activity and mechanisms of resistance to cefiderocol and combinations of β-lactams and the novel β-lactamase inhibitors avibactam, taniborbactam, zidebactam, nacubactam, xeruborbactam, and ANT3310 in emerging double-carbapenemase-producing Enterobacterales.
Antimicrob Agents Chemother
November 2024
Article Synopsis
- The study investigated the efficacy and resistance mechanisms of cefiderocol and new β-lactam/β-lactamase inhibitor combinations against strains of Enterobacterales producing multiple carbapenemases, specifically focusing on clinical samples from Spanish hospitals collected between 2017 and 2022.
- The analysis involved 57 isolates, where minimum inhibitory concentration (MIC) values were determined for various antibiotics, and whole-genome sequencing was utilized to identify genetic resistance factors.
- Ceftazidime/avibactam, imipenem/relebactam, and meropenem/vaborbactam showed the least activity, while combinations like aztreonam/avibactam and cefepime/zidebactam were
The combination of several therapeutic strategies is often seen as a good way to decrease resistance rates, since bacteria can more easily overcome single-drug treatments than multi-drug ones. This strategy is especially attractive when several targets and subpopulations are affected, as it is the case of persister cells, a subpopulation of bacteria able to transiently survive antibiotic exposures. This work aims to evaluate the potential of a repurposed anticancer drug, mitomycin C, combined with the lytic phage vB_KpnM-VAC13 in vitro and its safety in an in vivo murine model against two clinical isolates of this pathogen, one of them exhibiting an imipenem-persister phenotype.
View Article and Find Full Text PDFCorrigendum to "Activity of cefiderocol and innovative β-lactam/β-lactamase inhibitor combinations against isogenic strains of Escherichia coli expressing single and double β-lactamases under high and low permeability conditions" [International Journal of Antimicrobial Agents Volume 63, Issue 5 (2024) 107150].
Tania Blanco-Martín Isaac Alonso-García Lucía González-Pinto Michelle Outeda-García Paula Guijarro-Sánchez Belén Aracil
Int J Antimicrob Agents
August 2024
Article Synopsis
- CP-Eco isolates are a type of bacteria that can spread antibiotic resistance genes quickly and lead to infections that are hard to treat. This study aimed to analyze these isolates from Spain to learn more about their resistance and genetic makeup.
- A total of 90 isolates from various hospitals in Spain were examined for their antibiotic susceptibility and genetic characteristics. Notably, a common strain (ST131) was identified, with many isolates demonstrating resistance to multiple antibiotic groups.
- The research found that a significant number of isolates had complex genetic traits that contribute to their resistance, with some exhibiting virulence genes. The study underscores the concern of CP-Eco's ability to spread antibiotic resistance in both community and hospital settings.
Activity of cefiderocol and innovative β-lactam/β-lactamase inhibitor combinations against isogenic strains of Escherichia coli expressing single and double β-lactamases under high and low permeability conditions.
Tania Blanco-Martín Isaac Alonso-García Lucía González-Pinto Michelle Outeda-García Paula Guijarro-Sánchez Belén Aracil
Int J Antimicrob Agents
May 2024
Article Synopsis
- The study investigates the effectiveness of various antibiotics against E. coli strains that express clinically relevant β-lactamases, particularly focusing on the antibiotics cefiderocol and different β-lactam combinations.
- Researchers created 82 E. coli strains with different levels of outer membrane permeability and β-lactamase production to test antibiotic susceptibility using broth microdilution methods.
- Results showed that cefiderocol and certain β-lactam/β-lactamase inhibitor combinations were highly effective against most strains, even those with low permeability or multiple β-lactamases, while double-carbapenemase strains demonstrated significantly reduced antibiotic activity.