Publications by authors named "B Applegate"
Beginning in 2006, optical coherence tomography (OCT) has been adapted for use as a vibrometer for hearing research. The application of OCT in this field, particularly for studying cochlear mechanics, represents a revolutionary advance over previous technologies. OCT provides detailed evidence of the motions of components within the organ of Corti, extending beyond the first-encountered surface of observation.
View Article and Find Full Text PDFGut dysbiosis and an inflamed bowel are growing concerns in mammals, including dogs. Probiotic supplements have been used to restore the natural microbial community and improve gastrointestinal health. Biofilm formation, antimicrobial activities, and immunological responses of probiotics are crucial to improving gut health.
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- Endolymphatic hydrops, an increase in fluid within the cochlea, is a key feature of Meniere's disease, which causes symptoms like vertigo, fluctuating hearing loss, and tinnitus.
- The study explored the relationship between endolymphatic hydrops and cochlear synaptopathy (a type of hearing loss) using imaging techniques on transgenic mice subjected to blast noise and osmotic changes.
- Findings indicated that while both conditions can occur after noise exposure, endolymphatic hydrops does not cause cochlear synaptopathy; instead, they are independent effects resulting from damage to hair cell structures.
Neurofibromatosis type 2 (NF-2) is a dominantly inherited genetic disorder that results from variants in the tumor suppressor gene, neurofibromin 2 (NF2). Here, we report the generation of a conditional zebrafish model of neurofibromatosis established by inducible genetic knockout of nf2a/b, the zebrafish homologs of human NF2. Analysis of nf2a and nf2b expression revealed ubiquitous expression of nf2b in the early embryo, with overlapping expression in the neural crest and its derivatives and in the cranial mesenchyme.
View Article and Find Full Text PDFSignificance: Pathologies within the tympanic membrane (TM) and middle ear (ME) can lead to hearing loss. Imaging tools available in the hearing clinic for diagnosis and management are limited to visual inspection using the classic otoscope. The otoscopic view is limited to the surface of the TM, especially in diseased ears where the TM is opaque.
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