Publications by authors named "B Anupama"
The Role and Implications of COVID-19 in Incident and Prevalent Heart Failure.
Curr Heart Fail Rep
October 2024
Purpose Of Review: This review examines the pathophysiological interactions between COVID-19 and heart failure, highlighting the exacerbation of heart failure in COVID-19 patients. It focuses on the complex mechanisms driving worse outcomes in these patients.
Recent Findings: Patients with pre-existing heart failure experience more severe symptoms and higher mortality rates due to mechanisms such as cytokine storms, myocardial infarction, myocarditis, microvascular dysfunction, thrombosis, and stress cardiomyopathy.
Background: Mechanical neck pain (MNP) is one of the most prevalent musculoskeletal pathologies in the present time. Physiotherapy management strategies comprising manual therapy and exercise therapy are routinely administered in patients with MNP.
Objective: To compare the immediate effect of craniocervical flexion (CCF) exercise and Mulligan mobilisation on pain, active cervical range of motion (CROM) and CCF test performance in patients with MNP.
In silico elucidation of plausible anti-obesity activity by Withaferin-A compound targeting alpha-amylase.
Eur Rev Med Pharmacol Sci
April 2023
Article Synopsis
- The study evaluated Withaferin-A's interaction with the drug target α-amylase using a computational approach to determine its inhibitory potential and mechanisms of action.
- Various computational methods, including molecular dynamics simulations and docking, were employed to investigate the atomic-level details and pharmacological properties of Withaferin-A derived from W. somnifera.
- Results showed a strong binding affinity of Withaferin-A to α-amylase, identifying key molecular interactions that could inform future research on designing α-amylase inhibitors for potential anti-obesity applications.
Objective: The aim of the study is to design N5-(1H-pyrazol-3-yl)-3H-benzo[d]imidazole-2,5-diamine derivatives and evaluate its anti-obesity activity.
Materials And Methods: A few pyrazole-fused benzimidazole derivatives were designed as potential Pancreatic Lipase (PL) inhibitors. The designed N5-(1H-pyrazol-3-yl)-3H-benzo[d]imidazole-2,5-diamine derivatives have been screened using the Lipinski rule of five, ADMET analysis, acute toxicity prediction, and molecular docking.