Publications by authors named "B Ansell"
Article Synopsis
- Age-related macular degeneration (AMD) is a complex eye disease influenced by both genetic factors and involves a subtype called reticular pseudodrusen (RPD), which increases the risk of severe vision loss.* -
- A genome-wide association study compared genetic data from individuals with AMD and/or RPD to controls, finding significant associations specifically on chromosome 10, while chromosome 1 did not show this correlation in RPD cases.* -
- The chromosome 10 region includes a long non-coding RNA related to retinal health, highlighting its potential role in retinal thickness and influencing the outer segment of photoreceptors.*
Article Synopsis
- Reticular pseudodrusen (RPD) are a key factor in vision loss related to age-related macular degeneration (AMD), making their detection essential for effective clinical management.
- Researchers created a deep learning model that segments RPD from a dataset of 9,800 optical coherence tomography scans, achieving better agreement with retinal specialists compared to their own consensus.
- The model demonstrated high performance in detecting RPD across multiple test datasets, matching the accuracy of experienced specialists, and is now publicly accessible for use.
Article Synopsis
- Metabolic homeostasis relies on multiple pathways to supply nutrients during fasting and stress, regulated by organs like the liver and kidney.
- Research shows that serine and glycine metabolism is crucial for maintaining retinal amino acids, especially in individuals with macular telangiectasia (MacTel) who have genetic issues affecting SGOC enzymes.
- A mouse model with reduced serine synthesis exhibits faster retinal degeneration due to dietary restrictions, but serine supplementation can reverse retinopathy and neuropathy, suggesting potential therapies for neuro-retinal conditions.
Do national innovation projects shape citizens' public health behaviours?
Healthc Manage Forum
November 2024
This article investigates whether, in the context of rising nationalism, drawing attention to national innovation strategies influences public health behaviours, particularly vaccine uptake. It draws on an original two-wave panel study of United Kingdom (UK) respondents during the COVID pandemic. The survey included an experimental design, which primed respondents with a nationalist framing of COVID-19 vaccines, drawing attention to the UK's role in developing the AstraZeneca vaccine and in rapid approval and roll out of other vaccines.
View Article and Find Full Text PDFObjective: Abnormal changes in metabolite levels in serum or plasma have been highlighted in several studies in age-related macular degeneration (AMD), the leading cause of irreversible vision loss. Specific changes in lipid profiles are associated with an increased risk of AMD. Metabolites could thus be used to investigate AMD disease mechanisms or incorporated into AMD risk prediction models.
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