Facile synthesis of corticiolic acid-a bioactive pharmacophore from natural sources.

Fungal strains have inspired us to find the untapped sources of secondary metabolites. Corticiolic acid (CA, 2,4-dihydroxy-6-pentadecylbenzoic acid; from fungus, ) is one of the core active scaffolds in natural compounds such as Aquastatin-A, B, & C. CA can also be isolated from the plant .

NHC-Catalyzed Umpolung Driven Intramolecular Cyclizations for the Generation of 3,4-Cycloheptanone Annulated Tetracyclic Indole Derivatives.

In this Letter, we disclose the development and exploitation of umpolung reactivity of N-heterocyclic carbene (NHC) organocatalysts in generating tetracyclic indole derivatives with the introduction of a cycloheptane ring forming event. The NHC-catalyzed intramolecular vinylogous Stetter, Stetter, benzoin, and formal cross-dehydrogenative coupling transformations have been executed, enabling the construction of 3,4-cycloheptannulated indole derivatives in good to excellent yields. The developed protocols utilize an inexpensive catalyst and feature operational simplicity, atom economy, gram-scale syntheses, and postsynthetic availability.

Covid-19 classification using sigmoid based hyper-parameter modified DNN for CT scans and chest X-rays.

Coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. Diagnosis of Computed Tomography (CT), and Chest X-rays (CXR) contains the problem of overfitting, earlier diagnosis, and mode collapse. In this work, we predict the classification of the Corona in CT and CXR images.

Design, fabrication and performance assessment of a solar cooker with optimum composition of heat storage materials.

Solar energy as an inexhaustible source of energy has been the primary interest of many researchers for the last four to five decades due to its wide applications such as domestic cooking systems. The current work aims to determine the optimum cooker surface area with the aid of analytical heat loss and design equations. The top, bottom and side heat loss coefficients are calculated by an iterative procedure solved using MATLAB.

Gastrectomy with D2 Lymphadenectomy for Carcinoma of the Stomach in a Stand-alone Cancer Centre in Rural India.

Context: The therapeutic role of D2 lymphadenectomy in the management of gastric cancer is an ongoing controversy.

Aims: To examine the morbidity and oncological outcomes of D2 lymph node dissection for gastric cancer patients treated in a stand-alone cancer center in rural India and to compare it with international data.

Settings And Design: Retrospective study on patients treated for gastric cancer from June 2009 to December 2014.