Nox4 is involved in acute kidney injury associated to intravascular hemolysis.

Massive intravascular hemolysis occurs not unfrequently in many clinical conditions. Breakdown of erythrocytes promotes the accumulation of heme-derivates in the kidney, increasing oxidative stress and cell death, thus promoting acute kidney injury (AKI). NADPH oxidase 4 (Nox4) is a major source of reactive oxygen species (ROS) in the kidney, however it is unknown the role of Nox4 in hemolysis and whether inhibition of this enzyme may protect from heme-mediated injury.

Assessment of Changes in Selected Features of Pine and Birch Wood after Impregnation with Graphene Oxide.

In this work, pine and birch wood were modified by graphene oxide using a single vacuum impregnation method. The research results indicate that the impregnation of wood with graphene oxide increases the crystallinity of cellulose in both pine and birch wood, and the increase in crystallinity observed in the case of birch was more significant than in the case of pine. FT-IR analyses of pine samples impregnated with graphene oxide showed changes in intensity in the absorption bands of 400-600, 700-1500 cm, and 3200-3500 cm and a peak separation of 1102 cm, which may indicate new C-O-C connections.

Micronutrient deficiencies in older patients with inflammatory bowel disease are not associated with worse adverse clinical outcome rates.

Background: Micronutrient deficiencies (MNDs) and age have been previously separately associated with adverse clinical outcomes in patients with inflammatory bowel disease (IBD). However, previous clinical outcomes in older patients with MNDs have been poorly described. We examined the age-related rates of adverse clinical outcomes in patients with 1 or more MNDs.

Ultrafast spin transfer and its impact on the electronic structure.

Optically induced intersite spin transfer (OISTR) promises manipulation of spin systems within the ultimate time limit of laser excitation. Following its prediction, signatures of ultrafast spin transfer between oppositely aligned spin sublattices have been observed in magnetic alloys and multilayers. However, it is known neither from theory nor from experiment whether the band structure immediately follows the ultrafast change in spin polarization or whether the exchange split bands remain rigid.