Publications by authors named "B Amaechi"
Objectives: A systematic review and meta-analysis were undertaken to update our 3-year-old meta-analysis to include RCTs, in vivo, and in situ clinical evidence that showed hydroxyapatite in oral care products can reduce dental caries.
Data: Using the PICO guide, published clinical trials were searched where subjects (P) of all ages, with primary, mixed or permanent dentitions, using toothpastes, mouthwashes or gels containing hydroxyapatite as an active ingredient (I) were compared to subjects who used placebo or no intervention, or fluoride-containing positive controls (C), and the outcomes (O) were direct measurement of reduced dental caries or suitable proxy for reduced caries risk.
Sources: PubMed, Scopus, EMBASE, and Web of Science databases were searched using search terms from previous searches.
Article Synopsis
- There is a pressing need for effective treatments for denture stomatitis (DS) among denture wearers, and this study explores the use of nanohydroxyapatite (nanoHAP) nanoparticles to combat biofilm formation by Candida albicans on denture bases made of PMMA.
- The research involved creating shared conditions for testing where PMMA disks were treated with either an antibacterial denture cleanser, a nanoHAP mouthwash, or distilled water, and biofilm growth was analyzed through various microscopy techniques.
- Results indicated that nanoHAP mouthwash significantly inhibited biofilm formation and reduced biofilm biomass and thickness compared to other treatments, suggesting its potential effectiveness in preventing DS in clinical settings.
Article Synopsis
- This study analyzed how effective Isomalt-containing toothpaste is in preventing dental caries compared to traditional fluoride toothpaste.
- Human dental enamel slabs were tested under different conditions, using various toothpaste formulations over a week-long period with plaque exposure.
- Results showed that toothpaste with 10% Isomalt, fluoride, and CPC was significantly more effective at reducing demineralization and caries development than toothpaste containing only fluoride.
Clinical Evaluation of the Effect of Nanohydroxyapatite Lozenge on the pH of Dental Plaque.
Clin Cosmet Investig Dent
September 2024
Purpose: This study investigated the influence of nanohydroxyapatite-containing (nanoHAP) lozenge on plaque pH following sucrose intake.
Patients And Methods: Sixteen adult subjects were enrolled in this double-blind crossover study composed of four interventions: (1) 10% w/v sucrose solution, (2) 10% w/v sorbitol solution, (3) nanoHAP lozenge, and (4) 10% w/v sucrose solution challenge followed by nanoHAP lozenge. Following the determination of each subject's resting plaque pH, the pH was measured at different time intervals from 3 to 30 minutes from the start of intervention, with 7 days interval between the applications of different interventions.
Objectives: The effectiveness of an Isomalt-containing mouthrinse to prevent caries development was investigated.
Methods: Human enamel blocks were randomly assigned to five groups (n = 30/group): De-ionized distilled water (DDW), and mouthrinse containing either (IFC) 1% Isomalt, 225 ppm fluoride, and 0.05% cetylpyridinium chloride (CPC), (IF) 1% Isomalt and 225ppm fluoride, (FC) 225 ppm fluoride and 0.