Publications by authors named "B Allais"
Importance: UV-induced mutagenesis leads to a higher tumor mutational burden (TMB) in cutaneous melanoma relative to other cancer types. TMB is an important prognostic marker in advanced melanoma; higher TMB is associated with greater clinical response to immune checkpoint inhibition and improved survival.
Objective: To evaluate the association between cutaneous melanoma TMB and indoor tanning exposure, as well as other demographic, dermatologic, and tumor characteristics.
Importance: A multicenter randomized clinical trial (RCT) showed a lung recruitment maneuver using high-frequency oscillatory ventilation just before surfactant administration (ie, intubate-recruit-surfactant-extubate [IN-REC-SUR-E]) improved the efficacy of treatment compared with the standard intubate-surfactant-extubate (IN-SUR-E) technique without increasing the risk of adverse neonatal outcomes.
Objective: To examine follow-up outcomes at corrected postnatal age (cPNA) 2 years of preterm infants previously enrolled in an RCT and treated with IN-REC-SUR-E or IN-SUR-E in 35 tertiary neonatal intensive care units.
Design, Setting, And Participants: This was a follow-up study of infants recruited into the primary RCT from 2015 to 2018 at 35 tertiary neonatal intensive care units (NICUs) in Italy.
Article Synopsis
- * Conducting large-scale studies and improving diagnostic criteria can lead to better treatments and patient care, as these adverse events are linked to longer survival rates.
- * Collaboration among specialists, particularly dermatologists, is essential for enhancing research and care strategies for cancer patients experiencing these skin-related side effects.
Article Synopsis
- Protein kinase inhibitors and immunotherapy have significantly improved treatment outcomes for advanced melanoma, but they also introduce various drug-related toxicities.
- This review highlights dermatologic adverse events associated with targeted therapies (like BRAF and MEK inhibitors) and immunotherapy, including talimogene laherparepvec.
- Recognizing and managing these skin-related toxicities is crucial since they can affect patients' quality of life and are linked to treatment response and survival rates.
The impact of liquid drops on a rigid surface is central in cleaning, cooling, and coating processes in both nature and industrial applications. However, it is not clear how details of pores, roughness, and texture on the solid surface influence the initial stages of the impact dynamics. Here, we experimentally study drops impacting at low velocities onto surfaces textured with asymmetric (tilted) ridges.
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