Publications by authors named "B Alessandri"
Background: Subarachnoid hemorrhage (SAH) is a devastating disease with high morbidity and mortality. Neuroprotective effects of the noble gas argon have been shown in animal models of ischemia. The aim of this study was to investigate the effects of argon in the immediate early phase of SAH in a rat model.
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- The study investigates how different components of blood contribute to injury development following acute subdural hematoma (ASDH) in a rat model, focusing on factors like neuroinflammation and blood-brain barrier (BBB) integrity.
- Researchers infused various blood products into the subdural space and monitored cerebral blood flow (CBF), revealing a significant decline in CBF and larger lesion volumes in rats treated with corpuscular blood compared to those with plasmatic blood.
- Results indicated that corpuscular blood led to increased inflammation and BBB disruption, highlighting the need for timely surgical intervention and potential pharmacological treatments to mitigate damage from ASDH.
Objective: We aimed to investigate (1) whether an automated detector can capture scalp high-frequency oscillations (HFO) in neonates and (2) whether scalp HFO rates can differentiate neonates with seizures from healthy neonates.
Methods: We considered 20 neonates with EEG-confirmed seizures and four healthy neonates. We applied a previously validated automated HFO detector to determine scalp HFO rates in quiet sleep.
Objective: Acute subdural hematoma (ASDH) leads to the highest mortality rates of all head injuries with secondary brain damage playing a pivotal role in terms of morbidity and mortality. In patients with ASDH, a delay in surgery leads to disproportional mortality. The benefit of (very) early therapy is therefore, a target of ongoing research.
View Article and Find Full Text PDFtime course of organ uptake and blood-brain-barrier permeation of poly(L-lactide) and poly(perfluorodecyl acrylate) nanoparticles with different surface properties in unharmed and brain-traumatized rats.
Front Neurol
February 2023
Background: Traumatic brain injury (TBI) has a dramatic impact on mortality and quality of life and the development of effective treatment strategies is of great socio-economic relevance. A growing interest exists in using polymeric nanoparticles (NPs) as carriers across the blood-brain barrier (BBB) for potentially effective drugs in TBI. However, the effect of NP material and type of surfactant on their distribution within organs, the amount of the administrated dose that reaches the brain parenchyma in areas with intact and opened BBB after trauma, and a possible elicited inflammatory response are still to be clarified.
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