Publications by authors named "B Alberts"
The identification of individual protein-protein interactions (PPIs) began more than 40 years ago, using protein affinity chromatography and antibody co-immunoprecipitation. As new technologies emerged, analysis of PPIs increased to a genome-wide scale with the introduction of intracellular tagging methods, affinity purification (AP) followed by mass spectrometry (MS), and co-fractionation MS (CF-MS). Now, combining the resulting catalogs of interactions with complementary methods, including crosslinking MS (XL-MS) and cryogenic electron microscopy (cryo-EM), helps distinguish direct interactions from indirect ones within the same or between different protein complexes.
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- - Oral semaglutide was shown to improve cardiovascular risk factors in type 2 diabetes patients in a real-world setting, as evidenced by significant reductions in weight, blood pressure, and cholesterol levels over time.
- - A study involving 76 patients highlighted that the primary reasons for starting the medication were weight loss and improved blood sugar control, with positive results observed within 3-6 months and sustained improvements at the 6-12 month mark.
- - While 23.6% of patients discontinued the drug mainly due to gastrointestinal issues, there were no serious adverse events noted, supporting the medication's overall safety and effectiveness in this population.
Identifying opportunities to safely reduce antibiotic prescribing is necessary for prescribers and antibiotic stewardship teams to minimise unwarranted antibiotic use. We aimed to quantify excess antibiotic use in General Surgery. We retrospectively audited the antibiotic prescribing for patients discharged from the General Surgery specialty in an acute hospital in the south-west of England for one month using an audit tool developed by Public Health England.
View Article and Find Full Text PDFThe publication of papers containing data obtained with suboptimal rigor in the experimental design and choice of key reagents, such as antibodies, can result in a lack of reproducibility and generate controversy that can both needlessly divert resources and, in some cases, damage public perception of the scientific enterprise. This exemplary paper by Buonarati (2018) shows how a previously published, potentially important paper on calcium channel regulation falls short of the necessary mark, and aims to resolve the resulting controversy.
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